Cellosaurus BIC-1 (CVCL_8092)

Cell line name BIC-1
Synonyms Bic-1; BIC1; Bic1; BIC
Accession CVCL_8092
Resource Identification Initiative To cite this cell line use: BIC-1 (RRID:CVCL_8092)
Comments Problematic cell line: Contaminated. Shown to be a SW480 (or SW620) derivative (PubMed=20075370). Originally thought to originate from a esophageal adenocarcinoma.
Sequence variation: Homozygous for APC p.Gln1338Ter (from parent cell line).
Sequence variation: Homozygous for KRAS p.Gly12Val (from parent cell line).
Sequence variation: Heterozygous for TP53 p.Arg273His and p.Pro309Ser (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0546 (SW480)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): PubMed=20075370

Markers:
AmelogeninX
CSF1PO13,14
D13S31712
D16S5399,13
D18S5113
D21S1130,30.2
D3S135815,16
D5S81813
D7S8208,9
D8S117913
FGA24
Penta D9,15
Penta E10
TH018
TPOX11
vWA16
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations-v8_0.pdf
Publications

PubMed=9407969
Hughes S.J., Nambu Y., Soldes O.S., Hamstra D., Rehemtulla A., Iannettoni M.D., Orringer M.B., Beer D.G.
Fas/APO-1 (CD95) is not translocated to the cell membrane in esophageal adenocarcinoma.
Cancer Res. 57:5571-5578(1997)

PubMed=16364037; DOI=10.1111/j.1442-2050.2006.00530.x
Su M., Chin S.-F., Li X.-Y., Edwards P., Caldas C., Fitzgerald R.C.
Comparative genomic hybridization of esophageal adenocarcinoma and squamous cell carcinoma cell lines.
Dis. Esophagus 19:10-14(2006)

PubMed=20075370; DOI=10.1093/jnci/djp499
Boonstra J.J., van Marion R., Beer D.G., Lin L., Chaves P., Ribeiro C., Pereira A.D., Roque L., Darnton S.J., Altorki N.K., Schrump D.S., Klimstra D.S., Tang L.H., Eshleman J.R., Alvarez H., Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=23795680; DOI=10.1111/dote.12095
Boonstra J.J., Tilanus H.W., Dinjens W.N.M.
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

Cross-references
Ontologies BTO; BTO:0003429
Biological sample resources BioSample; SAMN03151929