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Cellosaurus FL-18 (CVCL_8093)

[Text version]

Cell line name FL-18
Synonyms FL18
Accession CVCL_8093
Resource Identification Initiative To cite this cell line use: FL-18 (RRID:CVCL_8093)
Comments Doubling time: 36-48 hours (PubMed=3928551); 25.3 hours (PubMed=8847894).
Omics: Transcriptome analysis.
Misspelling: AKA96-3; In IARC TP53 database: not really a misspelling but an assignment of a name based on first author of publication and date because assignment of correct cell line name was not done correctly.
Derived from sampling site: Pleural effusion.
Sequence variations TP53 p.Ser127Phe (c.380C>T) (PubMed=8878455).
Disease Follicular lymphoma (NCIt: C3209)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_J353 ! FL-18-EB
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line

PubMed=3928551; DOI=10.20772/cancersci1985.76.7_563
Ohno H., Doi S., Fukuhara S., Nishikori M., Uchino H., Fujii H.
A newly established human lymphoma cell line, FL-18, carrying a 14;18 translocation.
Jpn. J. Cancer Res. 76:563-566(1985)

Doi S., Ohno H., Tatsumi E., Arita Y., Kamesaki H., Fukuhara S., Nishikori M., Miwa H., Kita K., Hatanaka M., Honjo T., Fuji H., Uchino H.
Lymphoma cell line (FL-18) and Epstein-Barr virus-carrying cell line (FL-18-EB) obtained from a patient with follicular lymphoma: monoclonal derivation and different properties.
Blood 70:1619-1623(1987)

PubMed=3034807; DOI=10.1002/ijc.2910390622
Ohno H., Fukuhara S., Takahashi R., Mihara K.-I., Sugiyama T., Doi S., Uchino H., Toyoshima K.
c-yes and bcl-2 genes located on 18q21.3 in a follicular lymphoma cell line carrying a t(14;18) chromosomal translocation.
Int. J. Cancer 39:785-788(1987)

PubMed=1967982; DOI=10.1016/0092-8674(90)90657-Z
Nourse J., Mellentin J.D., Galili N., Wilkinson J., Stanbridge E.J., Smith S.D., Cleary M.L.
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.
Cell 60:535-545(1990)

Tani A., Tatsumi E., Nakamura F., Kumagai S., Kosaka Y., Sano K., Nakamura H., Amakawa R., Ohno H.
Sensitivity to dexamethasone and absence of bcl-2 protein in Burkitt's lymphoma cell line (Black93) derived from a patient with acute tumor lysis syndrome: comparative study with other BL and non-BL lines.
Leukemia 10:1592-1603(1996)

PubMed=8878455; DOI=10.1111/j.1349-7006.1996.tb02122.x
Akasaka T., Muramatsu M., Kadowaki N., Ohno H., Ishizaki K., Yamabe H., Fukuhara S., Okuma M.
p53 mutation in B-cell lymphoid neoplasms with reference to oncogene rearrangements associated with chromosomal translocations.
Jpn. J. Cancer Res. 87:930-937(1996)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12967475; DOI=10.1111/j.1349-7006.2003.tb01518.x
Maesako Y., Uchiyama T., Ohno H.
Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell lymphoma.
Cancer Sci. 94:774-781(2003)

PubMed=14990977; DOI=10.1038/sj.leu.2403323
Hardianti M.S., Tatsumi E., Syampurnawati M., Furuta K., Saigo K., Nakamachi Y., Kumagai S., Ohno H., Tanabe S., Uchida M., Yasuda N.
Activation-induced cytidine deaminase expression in follicular lymphoma: association between AID expression and ongoing mutation in FL.
Leukemia 18:826-831(2004)

PubMed=15028022; DOI=10.1111/j.1440-1827.2004.01612.x
Kamimura K., Hojo H., Abe M.
Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: relationship between its expression and prognosis.
Pathol. Int. 54:224-230(2004)

PubMed=26727417; DOI=10.3109/10428194.2015.1108414
Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Leuk. Lymphoma 57:1015-1020(2016)

Ontologies BTO; BTO:0002518
Other Wikidata; Q54834952
Polymorphism and mutation databases Cosmic; 2396144
IARC_TP53; 5999
Entry history
Entry creation04-Apr-2012
Last entry updated25-Feb-2019
Version number15