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Cellosaurus M14K (CVCL_8102)

Cell line name M14K
Synonyms M-14-K; M14
Accession CVCL_8102
Secondary accession CVCL_M199
Resource Identification Initiative To cite this cell line use: M14K (RRID:CVCL_8102)
Comments Doubling time: 55 hours (PubMed=23840376).
Transformant: ChEBI; CHEBI:46661; Asbestos.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Lung, pleura; UBERON=UBERON_0000977.
Sequence variations
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=1568228).
Disease Pleural epithelioid mesothelioma (NCIt: C45662)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_U345 ! M14P
CVCL_8103 ! M20 [Human mesothelioma]
Sex of cell Male
Age at sampling 43-61Y
Category Cancer cell line
Publications

PubMed=2323006; DOI=10.1093/carcin/11.4.673
Pelin-Enlund K., Husgafvel-Pursiainen K., Tammilehto L., Klockars M., Jantunen K., Gerwin B.I., Harris C.C., Tuomi T., Vanhala E., Mattson K., Linnainmaa K.
Asbestos-related malignant mesothelioma: growth, cytology, tumorigenicity and consistent chromosome findings in cell lines from five patients.
Carcinogenesis 11:673-681(1990)

PubMed=1568228
Metcalf R.A., Welsh J.A., Bennett W.P., Seddon M.B., Lehman T.A., Pelin-Enlund K., Linnainmaa K., Tammilehto L., Mattson K., Gerwin B.I., Harris C.C.
p53 and Kirsten-ras mutations in human mesothelioma cell lines.
Cancer Res. 52:2610-2615(1992)

PubMed=9533946; DOI=10.1165/ajrcmb.18.4.2943
Kahlos K., Anttila S., Asikainen T.M., Kinnula K., Raivio K.O., Mattson K., Linnainmaa K., Kinnula V.L.
Manganese superoxide dismutase in healthy human pleural mesothelium and in malignant pleural mesothelioma.
Am. J. Respir. Cell Mol. Biol. 18:570-580(1998)

CLPUB00243
Kahlos K.
The expression and possible role of manganese superoxide dismutase in malignant pleural mesothelioma.
Thesis PhD (1999), University of Oulu, Finland

PubMed=11251971; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1094>3.0.CO;2-M
Kettunen E., Nissen A.-M., Ollikainen T., Taavitsainen M., Tapper J., Mattson K., Linnainmaa K., Knuutila S., El-Rifai W.
Gene expression profiling of malignant mesothelioma cell lines: cDNA array study.
Int. J. Cancer 91:492-496(2001)

PubMed=11283936; DOI=10.1002/1097-0142(20010401)91:7<1349::AID-CNCR1138>3.0.CO;2-D
Kahlos K., Soini Y., Sormunen R., Kaarteenaho-Wiik R., Paakko P., Linnainmaa K., Kinnula V.L.
Expression and prognostic significance of catalase in malignant mesothelioma.
Cancer 91:1349-1357(2001)

PubMed=23840376; DOI=10.1371/journal.pone.0065903
Szulkin A., Nilsonne G., Mundt F., Wasik A.M., Souri P., Hjerpe A., Dobra K.
Variation in drug sensitivity of malignant mesothelioma cell lines with substantial effects of selenite and bortezomib, highlights need for individualized therapy.
PLoS ONE 8:E65903-E65903(2013)

PubMed=33567673; DOI=10.3390/cancers13040685
Keller M., Reis K., Hjerpe A., Dobra K., Aspenstrom P.
Cytoskeletal organization correlates to motility and invasiveness of malignant mesothelioma cells.
Cancers (Basel) 13:685.1-685.20(2021)

Cross-references
Anatomy/cell type resources BTO; BTO:0003999
Encyclopedic resources Wikidata; Q54903474
Polymorphism and mutation databases Cosmic; 733822
IARC_TP53; 23629
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number17