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Cellosaurus L3.3 (CVCL_8147)

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Cell line name L3.3
Synonyms L33
Accession CVCL_8147
Resource Identification Initiative To cite this cell line use: L3.3 (RRID:CVCL_8147)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 35 hours (PubMed=25984343).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations KRAS p.Gly12Asp (c.35G>A) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African82.98
Native American2.01
East Asian, North6.2
East Asian, South0
South Asian0
European, North2.94
European, South5.87
Disease Pancreatic adenosquamous carcinoma (NCIt: C5721)
Derived from metastatic site: Celiac axis lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_8148 (L3.2)
Children:
CVCL_8146 (L3.4)CVCL_0384 (L3.6pl)CVCL_8144 (L3.6sl)
Sex of cell Female
Age at sampling 77Y
Category Cancer cell line
Publications

PubMed=1544114; DOI=10.1002/1097-0142(19920415)69:8<2060::AID-CNCR2820690810>3.0.CO;2-E
Vezeridis M.P., Tzanakakis G.N., Meitner P.A., Doremus C.M., Tibbetts L.M., Calabresi P.
In vivo selection of a highly metastatic cell line from a human pancreatic carcinoma in the nude mouse.
Cancer 69:2060-2063(1992)

PubMed=15235133; DOI=10.1385/IJGC:34:1:27
Tzanakakis G.N., Margioris A.N., Tsatsakis A.M., Vezeridis M.P.
The metastatic potential of human pancreatic cell lines in the liver of nude mice correlates well with cathepsin B activity.
Int. J. Gastrointest. Cancer 34:27-38(2003)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources CCLE; L33_PANCREAS
DepMap; ACH-000685
Ontologies BTO; BTO:0004571
Biological sample resources BioSample; SAMN10988255
Chemistry resources PharmacoDB; L3.3_817_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887258
GEO; GSM888333
Other Wikidata; Q54901020
Polymorphism and mutation databases LiGeA; CCLE_547
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number17