Cellosaurus L3.3 (CVCL_8147)

Cell line name L3.3
Synonyms L33
Accession CVCL_8147
Resource Identification Initiative To cite this cell line use: L3.3 (RRID:CVCL_8147)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 35 hours (PubMed=25984343).
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Pancreatic adenosquamous carcinoma (NCIt: C5721)
Derived from metastatic site: Celiac axis lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_8148 (L3.2)
Children: CVCL_8146 (L3.4); CVCL_0384 (L3.6pl); CVCL_8144 (L3.6sl)
Sex of cell Female
Category Cancer cell line
Publications

PubMed=1544114; DOI=10.1002/1097-0142(19920415)69:8<2060::AID-CNCR2820690810>3.0.CO;2-E
Vezeridis M.P., Tzanakakis G.N., Meitner P.A., Doremus C.M., Tibbetts L.M., Calabresi P.
In vivo selection of a highly metastatic cell line from a human pancreatic carcinoma in the nude mouse.
Cancer 69:2060-2063(1992)

PubMed=15235133; DOI=10.1385/IJGC:34:1:27
Tzanakakis G.N., Margioris A.N., Tsatsakis A.M., Vezeridis M.P.
The metastatic potential of human pancreatic cell lines in the liver of nude mice correlates well with cathepsin B activity.
Int. J. Gastrointest. Cancer 34:27-38(2003)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

Cross-references
Cell line databases/resources CCLE; L33_PANCREAS
Ontologies BTO; BTO:0004571
Gene expression databases GEO; GSM887258
GEO; GSM888333