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Cellosaurus MOLT-15 (CVCL_8150)

[Text version]

Cell line name MOLT-15
Synonyms Molt-15; MOLT 15
Accession CVCL_8150
Resource Identification Initiative To cite this cell line use: MOLT-15 (RRID:CVCL_8150)
Comments Problematic cell line: Contaminated. Shown to be a CTV-1 derivative (PubMed=10508494; PubMed=12592342; PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00147.
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for FBXW7 p.Gly477Ser (c.1429G>A) and p.Arg505Cys (c.1513C>T) (ClinVar=VCV000069961) (from parent cell line).
Heterozygous for FLT3 p.Gly831Glu (c.2492G>A) (from parent cell line).
Heterozygous for LCK p.Ala353Val (c.1058C>T), p.Pro447Leu (c.1340C>T) and p.Ala500Thr (c.1498G>A) (from parent cell line).
Heterozygous for NF1 p.Gly1532Arg (c.4594G>A) (from parent cell line).
Heterozygous for NOTCH1 p.Ser2523Ter (c.7568C>A) (PubMed=15472075).
Heterozygous for PDGFRB p.Met772Ile (c.2316G>A) (from parent cell line).
Heterozygous for RET p.Cys656Phe (c.1967G>T) (from parent cell line).
Heterozygous for STK11 p.Arg75Met (c.224G>T) and p.Lys175Met (c.524A>T) (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1150 (CTV-1)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx
Publications

PubMed=2784121; DOI=10.1002/hon.2900070203
Drexler H.G., Minowada J.
Morphological, immunophenotypical and isoenzymatic profiles of human leukemia cells and derived T-cell lines.
Hematol. Oncol. 7:115-125(1989)

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7
Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.
Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.
Leuk. Res. 23:19-27(1999)

PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2
MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H., Drexler H.G.
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.
Int. J. Cancer 83:555-563(1999)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=15472075; DOI=10.1126/science.1102160
Weng A.P., Ferrando A.A., Lee W., Morris J.P. IV, Silverman L.B., Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Biological sample resources BioSample; SAMN03151632
Other Wikidata; Q54906346
Polymorphism and mutation databases Cosmic; 913415
Cosmic; 1524806
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number18