ID   Detroit 98/AH-2
AC   CVCL_8190
SY   Det98/AH-2; D98/AH-2; D98-AH2
DR   ATCC; CCL-18.3
DR   BioSample; SAMN03151682
DR   BioSample; SAMN03472006
DR   RCB; RCB2105
DR   TKG; TKG 0191
DR   Wikidata; Q54831009
RX   DOI=10.1007/BF02618370;
RX   PubMed=566722;
RX   PubMed=1246601;
RX   PubMed=13980043;
RX   PubMed=20143388;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Ancestral cell line (Detroit 98) has been shown to be a HeLa derivative (PubMed=566722; PubMed=1246601; PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00020.
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI:63486; 8-azaguanine.
CC   Selected for resistance to: ChEBI; CHEBI:136532; 8-azahypoxanthine.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Misspelling: Detroit 98/AT-2; PubMed=1246601.
CC   Discontinued: ATCC; CCL-18.3; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): RCB; TKG
ST   Amelogenin: X
ST   CSF1PO: 9,10 (TKG)
ST   CSF1PO: 9,10,11 (RCB)
ST   D13S317: 13.3
ST   D16S539: 9,10
ST   D5S818: 11,12
ST   D7S820: 12
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_8189 ! Detroit 98/AG
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 24
//
RX   DOI=10.1007/BF02618370;
RA   Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.;
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
//
RX   PubMed=566722; DOI=10.1007/BF02616110;
RA   Lavappa K.S.;
RT   "Survey of ATCC stocks of human cell lines for HeLa contamination.";
RL   In Vitro 14:469-475(1978).
//
RX   PubMed=1246601; DOI=10.1126/science.1246601;
RA   Nelson-Rees W.A., Flandermeyer R.R.;
RT   "HeLa cultures defined.";
RL   Science 191:96-98(1976).
//
RX   PubMed=13980043; DOI=10.1073/pnas.48.12.2026;
RA   Szybalska E.H., Szybalski W.;
RT   "Genetics of human cell line. IV. DNA-mediated heritable
RT   transformation of a biochemical trait.";
RL   Proc. Natl. Acad. Sci. U.S.A. 48:2026-2034(1962).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//