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Cellosaurus GLC-2 (CVCL_8207)

Cell line name GLC-2
Synonyms GLC 2; GLC2; OC-Ny; OC-NYH; NYH
Accession CVCL_8207
Resource Identification Initiative To cite this cell line use: GLC-2 (RRID:CVCL_8207)
Comments Doubling time: 37 hours (PubMed=2998591).
Omics: SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Unexplicit; Ex8del14; Zygosity=Unspecified (PubMed=10408787).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_0B24 (NYH/187/162)CVCL_0B25 (NYH/187/165)CVCL_0B26 (NYH/CAM)
CVCL_0B27 (NYH/CIS)CVCL_0B28 (NYH/TPT)CVCL_0B29 (NYH/VM)
Sex of cell Male
Age at sampling 41Y
Category Cancer cell line
STR profile Source(s): PubMed=24586258

Markers:
AmelogeninX,Y
CSF1PO12,13
D3S135817
D5S81812,13
D7S8209,12
D8S117912
D13S31714
D16S53912
D18S5115,18
D21S1130,32
FGA21,23
Penta D11,13
Penta E7,10
TH016,9.3
TPOX11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=2998591
de Leij L.F.M.H., Postmus P.E., Buys C.H.C.M., Elema J.D., Ramaekers F.C.S., Poppema S., Brouwer M., van der Veen A.Y., Mesander G., The T.H.
Characterization of three new variant type cell lines derived from small cell carcinoma of the lung.
Cancer Res. 45:6024-6033(1985)

PubMed=2473086; DOI=10.1242/jcs.91.1.91
Broers J.L.V., Rot M.K., Oostendorp T., Bepler G., de Leij L.F.M.H., Carney D.N., Vooijs G.P., Ramaekers F.C.S.
Spontaneous changes in intermediate filament protein expression patterns in lung cancer cell lines.
J. Cell Sci. 91:91-108(1988)

PubMed=2574988; DOI=10.1038/bjc.1989.376
Jensen P.B., Vindelov L.L., Roed H., Demant E.J.F., Sehested M., Skovsgaard T., Hansen H.H.
In vitro evaluation of the potential of aclarubicin in the treatment of small cell carcinoma of the lung (SCCL).
Br. J. Cancer 60:838-844(1989)

PubMed=1845952; DOI=10.1002/1097-0142(19910201)67:3<619::AID-CNCR2820670317>3.0.CO;2-Y
Broers J.L.V., Mijnheere E.P., Rot M.K., Schaart G., Sijlmans A., Boerman O.C., Ramaekers F.C.S.
Novel antigens characteristic of neuroendocrine malignancies.
Cancer 67:619-633(1991)

PubMed=1320893; DOI=10.1159/000163712
Verbeeck M.A.E., Elands J.P.M., de Leij L.F.M.H., Buys C.H.C.M., Carney D.N., Bepler G., Roebroek A.J.M., van de Ven W.J.M., Burbach J.P.H.
Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines.
Pathobiology 60:136-142(1992)

PubMed=9212023; DOI=10.1016/S0360-3016(97)00245-9
Krarup M., Poulsen H.S., Spang-Thomsen M.
Cellular radiosensitivity of small-cell lung cancer cell lines.
Int. J. Radiat. Oncol. Biol. Phys. 38:191-196(1997)

PubMed=9559344; DOI=10.1002/(SICI)1098-2264(199804)21:4<326::AID-GCC6>3.0.CO;2-0
Mulligan L.M., Timmer T., Ivanchuk S.M., Campling B.G., Young L.C., Rabbitts P.H., Sundaresan V., Hofstra R.M.W., Eng C.
Investigation of the genes for RET and its ligand complex, GDNF/GFR alpha-I, in small cell lung carcinoma.
Genes Chromosomes Cancer 21:326-332(1998)

PubMed=9744504; DOI=10.1038/bjc.1998.553
Damstrup L., Voldborg B.G.R., Spang-Thomsen M., Brunner N., Poulsen H.S.
In vitro invasion of small-cell lung cancer cell lines correlates with expression of epidermal growth factor receptor.
Br. J. Cancer 78:631-640(1998)

PubMed=10408787; DOI=10.1097/00019606-199903000-00002
Hayes V.M., Bleeker W., Verlind E., Timmer T., Karrenbeld A., Plukker J.T., Marx M.P., Hofstra R.M.W., Buys C.H.C.M.
Comprehensive TP53-denaturing gradient gel electrophoresis mutation detection assay also applicable to archival paraffin-embedded tissue.
Diagn. Mol. Pathol. 8:2-10(1999)

PubMed=10709110; DOI=10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O
McLaughlin P.M.J., Helfrich W., Kok K., Mulder M., Hu S.W., Brinker M.G.L., Ruiters M.H.J., de Leij L.F.M.H., Buys C.H.C.M.
The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines.
Int. J. Cancer 85:871-876(2000)

PubMed=12712436; DOI=10.1002/ijc.11106
Hansen L.T., Lundin C., Spang-Thomsen M., Petersen L.N., Helleday T.
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.
Int. J. Cancer 105:472-479(2003)

PubMed=24586258; DOI=10.1371/journal.pone.0086910
Murmann-Konda T., Carrillo-Garcia C., Veit N., Courts C., Glassmann A., Janzen V., Madea B., Reinartz M., Harzen A., Nowak M., Perner S., Winter J., Probstmeier R.
Staurosporine and extracellular matrix proteins mediate the conversion of small cell lung carcinoma cells into a neuron-like phenotype.
PLoS ONE 9:E86910-E86910(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8207
Anatomy/cell type resources BTO; BTO:0005499
Encyclopedic resources Wikidata; Q54835902
Gene expression databases GEO; GSM986182
Polymorphism and mutation databases Cosmic; 1759250
Cosmic; 2239119
Cosmic; 2648015
IARC_TP53; 11280
Progenetix; CVCL_8207
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number19