Home  |  Contact

Cellosaurus Hu609 (CVCL_8240)

[Text version]

Cell line name Hu609
Synonyms HU609; Hu 609; HU 609
Accession CVCL_8240
Resource Identification Initiative To cite this cell line use: Hu609 (RRID:CVCL_8240)
Comments Problematic cell line: Contaminated. Shown to be a J82 derivative (PubMed=7905254; PubMed=20143388). Originally thought to originate from the histologically normal ureter of a female patient with clear cell renal carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00131.
Sequence variations Mutation; HGNC; 583; APC; Simple; p.Ser770Pro (c.2308T>C); ClinVar=VCV000140988; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro124Leu (c.371C>T); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 9588; PTEN; Simple; p.Asn212fs*1 (c.635_1212del578); Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 9884; RB1; Simple; c.2107-2A>G; ClinVar=VCV000013077; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Glu271Lys (c.811G>A); ClinVar=VCV000406566; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Lys320Asn (c.960G>C); Zygosity=Heterozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0359 (J82)
Children:
CVCL_8241 (Hu609T)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): PubMed=11416159

Markers:
AmelogeninX,Y
D8S11798,13
D18S5110,12
D21S1130,31
FGA20,24
TH019.3
vWA17,18

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx
Publications

PubMed=7262169; DOI=10.1016/0014-2964(81)90123-7
Vilien M., Wolf H., Rasmussen F.
Immunological characterization of cell lines establishing from malignant and normal human urothelium.
Eur. J. Cancer 17:321-327(1981)

PubMed=6546195; DOI=10.1007/BF00121494
Schroyens W., Mareel M.M., Dragonetti C.
In vitro invasiveness of human bladder cancer from cell lines and biopsy specimens.
Clin. Exp. Metastasis 1:153-162(1983)

PubMed=3708594
Masters J.R.W., Hepburn P.J., Walker L., Highman W.J., Trejdosiewicz L.K., Povey S., Parkar M., Hill B.T., Riddle P.R., Franks L.M.
Tissue culture model of transitional cell carcinoma: characterization of twenty-two human urothelial cell lines.
Cancer Res. 46:3630-3636(1986)

PubMed=3800330
Debiec-Rychter M., Christensen B., Kieler J., Wang C.Y.
Chromosomal characterization and isoenzyme pattern of non-malignant and malignant human urothelial cell lines.
Anticancer Res. 6:1237-1244(1986)

PubMed=7905254
Christensen B., Hansen C., Kieler J., Schmidt J.
Identity of non-malignant human urothelial cell lines classified as transformation grade I (TGrI) and II (TGrII).
Anticancer Res. 13:2187-2191(1993)

PubMed=8105864; DOI=10.1038/bjc.1993.449
Christensen B., Hansen C., Debiec-Rychter M., Kieler J., Ottensen S., Schmidt J.
Identity of tumorigenic human urothelial cell lines and 'spontaneously' transformed sublines.
Br. J. Cancer 68:879-884(1993)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources Lonza; 245
Biological sample resources BioSample; SAMN03151802
Other Wikidata; Q54896703
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number22