AC   CVCL_8262
SY   MAR-24H; MAR 24H; MAR24H; 24H
DR   BioSample; SAMN03151913
DR   Cosmic; 2648018
DR   Wikidata; Q54952446
RX   PubMed=1845952;
RX   PubMed=2438285;
RX   PubMed=2473086;
RX   PubMed=3029138;
RX   PubMed=9744504;
RX   PubMed=10508494;
RX   PubMed=11414198;
RX   PubMed=12712436;
RX   PubMed=20143388;
RX   PubMed=24586258;
CC   Problematic cell line: Contaminated. Shown to be a SCLC-21H (or SCLC-22H) derivative (PubMed=10508494; PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00159.
CC   Doubling time: 70-75 hours, depending on growth medium (PubMed=3029138).
CC   Derived from metastatic site: Pleural effusion.
ST   Source(s): PubMed=24586258
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 12
ST   D16S539: 12
ST   D18S51: 14,15
ST   D21S11: 29,31.2
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 11
ST   D8S1179: 12,13
ST   FGA: 22,23
ST   Penta D: 9
ST   Penta E: 12,13
ST   TH01: 9.3
ST   TPOX: 8,9
ST   vWA: 17
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0024 ! SCLC-21H
SX   Male
AG   46Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 23-09-21; Version: 18
RX   PubMed=1845952; DOI=10.1002/1097-0142(19910201)67:3<619::AID-CNCR2820670317>3.0.CO;2-Y;
RA   Broers J.L.V., Mijnheere E.P., Rot M.K., Schaart G., Sijlmans A.,
RA   Boerman O.C., Ramaekers F.C.S.;
RT   "Novel antigens characteristic of neuroendocrine malignancies.";
RL   Cancer 67:619-633(1991).
RX   PubMed=2438285; DOI=10.1007/BF00396382;
RA   Bepler G., Jaques G., Koehler A., Gropp C., Havemann K.;
RT   "Markers and characteristics of human SCLC cell lines. Neuroendocrine
RT   markers, classical tumor markers, and chromosomal characteristics of
RT   permanent human small cell lung cancer cell lines.";
RL   J. Cancer Res. Clin. Oncol. 113:253-259(1987).
RX   PubMed=2473086; DOI=10.1242/jcs.91.1.91;
RA   Broers J.L.V., Rot M.K., Oostendorp T., Bepler G., de Leij L.F.M.H.,
RA   Carney D.N., Vooijs G.P., Ramaekers F.C.S.;
RT   "Spontaneous changes in intermediate filament protein expression
RT   patterns in lung cancer cell lines.";
RL   J. Cell Sci. 91:91-108(1988).
RX   PubMed=3029138; DOI=10.1007/BF00389964;
RA   Bepler G., Jaques G., Neumann K., Aumuller G., Gropp C., Havemann K.;
RT   "Establishment, growth properties, and morphological characteristics
RT   of permanent human small cell lung cancer cell lines.";
RL   J. Cancer Res. Clin. Oncol. 113:31-40(1987).
RX   PubMed=9744504; DOI=10.1038/bjc.1998.553;
RA   Damstrup L., Rude Voldborg B., Spang-Thomsen M., Brunner N.,
RA   Skovgaard Poulsen H.;
RT   "In vitro invasion of small-cell lung cancer cell lines correlates
RT   with expression of epidermal growth factor receptor.";
RL   Br. J. Cancer 78:631-640(1998).
RX   PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2;
RA   MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H.,
RA   Drexler H.G.;
RT   "Widespread intraspecies cross-contamination of human tumor cell lines
RT   arising at source.";
RL   Int. J. Cancer 83:555-563(1999).
RX   PubMed=11414198; DOI=10.1007/s004320000207;
RA   Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H.,
RA   Wolf E., Gabius H.J.;
RT   "Comprehensive galectin fingerprinting in a panel of 61 human tumor
RT   cell lines by RT-PCR and its implications for diagnostic and
RT   therapeutic procedures.";
RL   J. Cancer Res. Clin. Oncol. 127:375-386(2001).
RX   PubMed=12712436; DOI=10.1002/ijc.11106;
RA   Hansen L.T., Lundin C., Spang-Thomsen M., Petersen L.N., Helleday T.;
RT   "The role of RAD51 in etoposide (VP16) resistance in small cell lung
RT   cancer.";
RL   Int. J. Cancer 105:472-479(2003).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
RX   PubMed=24586258; DOI=10.1371/journal.pone.0086910;
RA   Murmann T., Carrillo-Garcia C., Veit N., Courts C., Glassmann A.,
RA   Janzen V., Madea B., Reinartz M., Harzen A., Nowak M., Perner S.,
RA   Winter J., Probstmeier R.;
RT   "Staurosporine and extracellular matrix proteins mediate the
RT   conversion of small cell lung carcinoma cells into a neuron-like
RT   phenotype.";
RL   PLoS ONE 9:E86910-E86910(2014).