Home  |  Contact

Cellosaurus UTMB-460 (CVCL_8276)

Cell line name UTMB-460
Accession CVCL_8276
Resource Identification Initiative To cite this cell line use: UTMB-460 (RRID:CVCL_8276)
Comments Problematic cell line: Contaminated. Shown to be a CCRF-CEM derivative (PubMed=12592342; PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00283.
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for FLT3 p.Ala627Thr (c.1879G>A) (from parent cell line).
Heterozygous for KRAS p.Gly12Asp (c.35G>A) (from parent cell line).
Heterozygous for TP53 p.Arg175His (c.524G>A) and p.Arg248Gln (c.743G>A) (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=3022081; DOI=10.1016/0145-2126(86)90239-0
Juneja H.S., Rajaraman S., Ramsey K.M., Elder F.F.B.
Role of marrow stromal cells in the establishment of a transformed lymphoblastic B-cell line from a normal human subject.
Leuk. Res. 10:1209-1219(1986)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Biological sample resources BioSample; SAMN03151622
Other Wikidata; Q54992238