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Cellosaurus ATL-2 (CVCL_8338)

Cell line name ATL-2
Synonyms ATL-2(+); ATL2
Accession CVCL_8338
Resource Identification Initiative To cite this cell line use: ATL-2 (RRID:CVCL_8338)
Comments Population: Japanese.
Characteristics: IL2 dependent.
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Donor information: Established from a patient suffering from adult T-cell leukemia/lymphoma (ATLL).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A6TF (ATL-2(-))CVCL_A7QA (ATL-2/ADM cl-1)CVCL_A7QB (ATL-2/ADM cl-2)
Sex of cell Sex unspecified
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=2866223; DOI=10.1084/jem.162.6.2169
Maeda M., Shimizu A., Ikuta K., Okamoto H., Kashihara M., Uchiyama T., Honjo T., Yodoi J.
Origin of human T-lymphotrophic virus I-positive T cell lines in adult T cell leukemia. Analysis of T cell receptor gene rearrangement.
J. Exp. Med. 162:2169-2174(1985)

PubMed=9116292; DOI=10.1182/blood.V89.7.2480
Wang J.-X., Kobayashi M., Sakurada K., Imamura M., Moriuchi T., Hosokawa M.
Possible roles of an adult T-cell leukemia (ATL)-derived factor/thioredoxin in the drug resistance of ATL to adriamycin.
Blood 89:2480-2487(1997)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Majka M., Rozmyslowicz T., Honczarenko M., Ratajczak J., Wasik M.A., Gaulton G.N., Ratajczak M.Z.
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

PubMed=11737246; DOI=10.1034/j.1600-0609.2001.5790522.x
Rozmyslowicz T., Kijowski J., Conover D.O., Majka M., Baj-Krzyworzeka M., Reca R., Libura J.J., Gaulton G.N., Ratajczak M.Z.
New T-lymphocytic cell lines for studying cell infectability by human immunodeficiency virus.
Eur. J. Haematol. 67:142-151(2001)

PubMed=16314839; DOI=10.1038/sj.onc.1209256
Ahsan M.K., Masutani H., Yamaguchi Y., Kim Y.-C., Nosaka K., Matsuoka M., Nishinaka Y., Maeda M., Yodoi J.
Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of thioredoxin-binding protein-2.
Oncogene 25:2181-2191(2006)

PubMed=32210945; DOI=10.3389/fmicb.2020.00356
Maeda M., Tanabe-Shibuya J., Miyazato P., Masutani H., Yasunaga J.-i., Usami K., Shimizu A., Matsuoka M.
IL-2/IL-2 receptor pathway plays a crucial role in the growth and malignant transformation of HTLV-1-infected T cells to develop adult T-cell leukemia.
Front. Microbiol. 11:356.1-356.17(2020)

Cross-references
Cell line collections (Providers) RCB; RCB3545
Encyclopedic resources Wikidata; Q54751258
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number17