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Cellosaurus SAM-1 (CVCL_8440)

Cell line name SAM-1
Accession CVCL_8440
Resource Identification Initiative To cite this cell line use: SAM-1 (RRID:CVCL_8440)
Comments Problematic cell line: Contaminated. Shown to be a K-562 derivative (PubMed=12412578; PubMed=12592342; PubMed=20143388). Originally thought to originate from the peripheral blood of a 22 year old male patient with chronic myelogenous leukemia.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00265.
Derived from sampling site: Pleural effusion.
Sequence variations Homozygous for TP53 p.Gln136fs*13 (c.406_407insC) (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=8562972
Kamesaki H., Michaud G.Y., Irving S.G., Suwabe N., Kamesaki S., Okuma M., Cossman J.
TPA-induced arrest of erythroid differentiation is coupled with downregulation of GATA-1 and upregulation of GATA-2 in an erythroid cell line SAM-1.
Blood 87:999-1005(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12412578; DOI=10.1182/blood-2002-07-2328
Alvarez S., MacGrogan D., Rodriguez-Perales S., Martinez-Ramirez A., Urioste M., Benitez J., Nimer S.D., Cigudosa J.C.
Cytogenetic characterization reveals that the SAM-1 erythroid cell line is derived from K-562 cells.
Blood 100:3435-3436(2002)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Biological sample resources BioSample; SAMN03151813
Other Wikidata; Q54952086