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Cellosaurus HOC719 (CVCL_8700)

[Text version]
Cell line name HOC719
Accession CVCL_8700
Resource Identification Initiative To cite this cell line use: HOC719 (RRID:CVCL_8700)
Comments Population: Japanese.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
Sequence variations
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Met1043Val (c.3127A>G); ClinVar=VCV000376485; Zygosity=Homozygous (PubMed=18097548).
  • Mutation; HGNC; 11998; TP53; Simple; p.Asp281Glu (c.843C>G); ClinVar=VCV000376587; Zygosity=Unspecified (PubMed=1570156).
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_8701 (HOC719-NE)CVCL_8702 (HOC719-PE)
Category Cancer cell line
Publications

PubMed=1570156
Sakai E., Tsuchida N.
Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.
Oncogene 7:927-933(1992)

PubMed=11120485; DOI=10.1016/S1368-8375(00)00059-2
Yokoyama K., Kamata N., Hayashi E., Hoteiya T., Ueda N., Fujimoto R., Nagayama M.
Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro.
Oral Oncol. 37:65-71(2001)

PubMed=18097548; DOI=10.3892/ijo.32.1.101
Murugan A.K., Hong N.T., Fukui Y., Munirajan A.K., Tsuchida N.
Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas.
Int. J. Oncol. 32:101-111(2008)

Cross-references
Encyclopedic resources Wikidata; Q54890116
Polymorphism and mutation databases Cosmic; 1123034
IARC_TP53; 1098
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number14