Cellosaurus cell line HOC815 (CVCL_8703)

• Mutation; HGNC; 11998; TP53; Simple; p.Tyr205Cys (c.614A>G); ClinVar=VCV000376681; Zygosity=Unspecified (PubMed=1570156).
  

PubMed=1570156
Sakai E., Tsuchida N.
Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.
Oncogene 7:927-933(1992)

PubMed=1624295; DOI=10.1002/hed.2880140103
Rikimaru K., Tadokoro K., Yamamoto T., Enomoto S., Tsuchida N.
Gene amplification and overexpression of epidermal growth factor receptor in squamous cell carcinoma of the head and neck.
Head Neck 14:8-13(1992)

PubMed=17052259; DOI=10.1111/j.1349-7006.2006.00343.x
Kozaki K.-i., Imoto I., Pimkhaokham A., Hasegawa S., Tsuda H., Omura K., Inazawa J.
PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma.
Cancer Sci. 97:1351-1358(2006)

PubMed=17599052; DOI=10.1038/sj.onc.1210589
Suzuki E., Imoto I., Pimkhaokham A., Nakagawa T., Kamata N., Kozaki K.-i., Amagasa T., Inazawa J.
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Oncogene 26:7921-7932(2007)

PubMed=18097548; DOI=10.3892/ijo.32.1.101
Murugan A.K., Hong N.T., Fukui Y., Munirajan A.K., Tsuchida N.
Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas.
Int. J. Oncol. 32:101-111(2008)