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Cellosaurus HP50-2 (CVCL_8711)

[Text version]
Cell line name HP50-2
Synonyms HL60 HP50-2
Accession CVCL_8711
Resource Identification Initiative To cite this cell line use: HP50-2 (RRID:CVCL_8711)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:16240; Hydrogen peroxide.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): RCB

Markers:
AmelogeninX
CSF1PO13,14
D5S81812
D7S82011,12
D13S3178,11
D16S53911
TH018
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=2796382; DOI=10.1016/0145-2126(89)90088-X
Kasugai I., Yamada M.
Adaptation of human leukemia HL-60 cells to hydrogen peroxide as oxidative stress.
Leuk. Res. 13:757-762(1989)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

Cross-references
Cell line collections (Providers) RCB; RCB0768
Cell line databases/resources CLO; CLO_0050977
cancercelllines; CVCL_8711
Encyclopedic resources Wikidata; Q54890203
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number26