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Cellosaurus IGROV-1/25 ET (CVCL_8723)

Cell line name IGROV-1/25 ET
Synonyms Igrov-1/25 ET
Accession CVCL_8723
Resource Identification Initiative To cite this cell line use: IGROV-1/25 ET (RRID:CVCL_8723)
Comments Doubling time: ~23 hours (PubMed=10817511).
Selected for resistance to: ChEBI; CHEBI:84050; Trabectedin (Ecteinascidin-743; ET-743).
Sequence variations Heterozygous for BRCA1 p.Lys654fs*47 (c.1961delA) (from parent cell line).
Heterozygous for SMAD4 p.Gly231fs*10 (c.692delG) (from parent cell line).
Heterozygous for PTEN p.Thr319fs*1 (c.955_958delACTT) (from parent cell line).
Heterozygous for TP53 p.Tyr126Cys (c.377A>G) (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1304 (IGROV-1)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line

PubMed=10817511; DOI=10.1054/bjoc.2000.1224
Erba E., Bergamaschi D., Bassano L., Ronzoni S., Di Liberti G., Muradore I., Vignati S., Faircloth G.T., Jimeno J., D'Incalci M.
Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743).
Br. J. Cancer 82:1732-1739(2000)

Other Wikidata; Q54897383