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Cellosaurus M-MOK (CVCL_8731)

[Text version]
Cell line name M-MOK
Accession CVCL_8731
Resource Identification Initiative To cite this cell line use: M-MOK (RRID:CVCL_8731)
Comments Population: Japanese.
Characteristics: Requires human fibroblast feeder cells for its viability.
Characteristics: CSF2 dependent.
Doubling time: 45 +- 6 hours (PubMed=9096695).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Disease Childhood acute megakaryoblastic leukemia (NCIt: C7972)
Acute megakaryoblastic leukemia (ORDO: Orphanet_518)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_RM05 (M-MOK/TPO)
Sex of cell Female
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): RCB; TKG

Markers:
AmelogeninX
CSF1PO12
D5S8189,11
D7S82010
D13S31712,14
D16S53910,12
TH017
TPOX11,12
vWA17,18

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Publications

PubMed=7589286
Itano M., Tsuchiya S., Minegishi N., Fujie H., Minegishi M., Morita S., Yambe T., Ohashi Y., Masuda T., Koike T., Konno T.
Establishment and characterization of a novel human immature megakaryoblastic leukemia cell line, M-MOK, dependent on fibroblasts for its viability.
Exp. Hematol. 23:1301-1309(1995)

PubMed=8558913
Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M., Imaizumi M., Endo M., Takano N., Konno T.
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

PubMed=9096695; DOI=10.1038/sj.leu.2400621
Drexler H.G., Zaborski M., Quentmeier H.
Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines.
Leukemia 11:541-551(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

Cross-references
Cell line collections (Providers) RCB; RCB2534
TKG; TKG 0458
Cell line databases/resources CLO; CLO_0051548
Biological sample resources BioSample; SAMN03471920
Encyclopedic resources Wikidata; Q38518614
Polymorphism and mutation databases Cosmic; 787456
Cosmic; 975273
Cosmic; 1281331
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number14