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Cellosaurus OV1/VCR (CVCL_8746)

Cell line name OV1/VCR
Accession CVCL_8746
Resource Identification Initiative To cite this cell line use: OV1/VCR (RRID:CVCL_8746)
Comments Selected for resistance to: ChEBI; CHEBI:28445; Vincristine (VCR).
Sequence variations Heterozygous for BRCA1 p.Lys654fs*47 (c.1961delA) (from parent cell line).
Heterozygous for SMAD4 p.Gly231fs*10 (c.692delG) (from parent cell line).
Heterozygous for PTEN p.Thr319fs*1 (c.955_958delACTT) (from parent cell line).
Heterozygous for TP53 p.Tyr126Cys (c.377A>G) (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1304 (IGROV-1)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line

PubMed=2731146; DOI=10.1016/0165-4608(89)90227-6
Teyssier J.-R., Benard J., Ferre D., Da Silva J., Renaud L.
Drug-related chromosomal changes in chemoresistant human ovarian carcinoma cells.
Cancer Genet. Cytogenet. 39:35-43(1989)

PubMed=2925277; DOI=10.1002/ijc.2910430322
Benard J., Da Silva J., Teyssier J.-R., Riou G.
Over-expression of MDR1 gene with no DNA amplification in a multiple-drug-resistant human ovarian carcinoma cell line.
Int. J. Cancer 43:471-477(1989)

PubMed=17934650; DOI=10.1590/S0100-879X2007001100014
Ait M'barek L., Ait Mouse H., Jaafari A., Aboufatima R., Benharref A., Kamal M., Benard J., El Abbadi N., Bensalah M., Gamouh A., Chait A., Dalal A., Zyad A.
Cytotoxic effect of essential oil of thyme (Thymus broussonettii) on the IGR-OV1 tumor cells resistant to chemotherapy.
Braz. J. Med. Biol. Res. 40:1537-1544(2007)

Other Wikidata; Q54936879