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Cellosaurus OCI-Ly4 (CVCL_8801)

[Text version]

Cell line name OCI-Ly4
Synonyms OCI-LY4; OCI-LY-4; OCI-Ly 4; Ly4; LY4
Accession CVCL_8801
Resource Identification Initiative To cite this cell line use: OCI-Ly4 (RRID:CVCL_8801)
Comments From: Ontario Cancer Institute (OCI); Toronto; Canada.
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: miRNA expression profiling.
Omics: Transcriptome analysis.
Derived from sampling site: Bone marrow.
Sequence variations TP53 p.Met237Ile (c.711G>T) (ClinVar=VCV000634770) and p.Arg248Gln (c.743G>A) (ClinVar=VCV000012356) (PubMed=8574164).
Disease Diffuse large B-cell lymphoma (NCIt: C8851)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 21Y
Category Cancer cell line
Web pages http://www.innovationbridge.com/uhn/diffuse-large-b-cell-lymphoma-cell-lines?categories=32&communities=5&forums=&organizations=&tags=
Publications

PubMed=3567358; DOI=10.1182/blood.V69.5.1307.1307
Tweeddale M.E., Lim B., Jamal N., Robinson J., Zalcberg J.R., Lockwood G., Minden M.D., Messner H.A.
The presence of clonogenic cells in high-grade malignant lymphoma: a prognostic factor.
Blood 69:1307-1314(1987)

PubMed=8574164; DOI=10.3109/10428199509059672
Chang H., Blondal J.A., Benchimol S., Minden M.D., Messner H.A.
p53 mutations, c-myc and bcl-2 rearrangements in human non-Hodgkin's lymphoma cell lines.
Leuk. Lymphoma 19:165-171(1995)

PubMed=11807979; DOI=10.1002/gcc.10025
Mehra S., Messner H.A., Minden M.D., Chaganti R.S.K.
Molecular cytogenetic characterization of non-Hodgkin lymphoma cell lines.
Genes Chromosomes Cancer 33:225-234(2002)

PubMed=19278952; DOI=10.1182/blood-2009-01-202028
Li C., Kim S.-W., Rai D., Bolla A.R., Adhvaryu S., Kinney M.C., Robetorye R.S., Aguiar R.C.T.
Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.
Blood 113:6681-6690(2009)

Cross-references
Gene expression databases GEO; GSM380134
GEO; GSM552452
GEO; GSM1035332
GEO; GSM1374788
Other Wikidata; Q54931774
Polymorphism and mutation databases Cosmic; 1517648
Cosmic; 1541902
Cosmic; 1636684
Cosmic; 2276330
IARC_TP53; 6447
Entry history
Entry creation06-Jun-2012
Last entry update02-Jul-2020
Version number17