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Cellosaurus NB4-LR1 (CVCL_8811)

[Text version]

Cell line name NB4-LR1
Synonyms NB4-RAr; NB4-R1
Accession CVCL_8811
Resource Identification Initiative To cite this cell line use: NB4-LR1 (RRID:CVCL_8811)
Comments Derived from sampling site: Bone marrow.
Sequence variations PML-RARA gene fusion (from parent cell line).
Heterozygous for KRAS p.Ala18Asp (c.53C>A) (from parent cell line).
Homozygous for TP53 p.Arg248Gln (c.743G>A) (ClinVar=VCV000012356) (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0005 (NB4)
CVCL_U081 (NB4-LR2)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line

Duprez E., Ruchaud S., Houge G., Martin-Thouvenin V., Valensi F., Kastner P., Berger R., Lanotte M.
A retinoid acid 'resistant' t(15;17) acute promyelocytic leukemia cell line: isolation, morphological, immunological, and molecular features.
Leukemia 6:1281-1287(1992)

PubMed=7915840; DOI=10.1073/pnas.91.18.8428
Ruchaud S., Duprez E., Gendron M.C., Houge G., Genieser H.G., Jastorff B., Doskeland S.O., Lanotte M.
Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.
Proc. Natl. Acad. Sci. U.S.A. 91:8428-8432(1994)

Bruel A., Benoit G., De Nay D., Brown S., Lanotte M.
Distinct apoptotic responses in maturation sensitive and resistant t(15;17) acute promyelocytic leukemia NB4 cells. 9-cis retinoic acid induces apoptosis independent of maturation and Bcl-2 expression.
Leukemia 9:1173-1184(1995)

PubMed=11704857; DOI=10.1038/sj.onc.1204863
Roussel M.J., Lanotte M.
Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes.
Oncogene 20:7287-7291(2001)

Ontologies BTO; BTO:0006043
Other Wikidata; Q54907532
Entry history
Entry creation06-Jun-2012
Last entry update02-Jul-2020
Version number13