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Cellosaurus YD-10B (CVCL_8929)

[Text version]

Cell line name YD-10B
Synonyms YD10B
Accession CVCL_8929
Resource Identification Initiative To cite this cell line use: YD-10B (RRID:CVCL_8929)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 25.3 hours (PubMed=16264262).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for CDKN2A p.Glu88Ter (c.262G>T) and p.Trp110Ter (c.330G>A) (p.Gly125Arg; c.373G>A) (CCLE).
Homozygous for TP53 p.Tyr236Ter (c.708C>A) (PubMed=16264262; CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North62.45
East Asian, South36.59
South Asian0
European, North0
European, South0.96
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): KCLB; PubMed=16264262

Markers:
AmelogeninX,Y
CSF1PO12,13
D3S135817
D5S81811,13
D7S82011
D8S117911
D13S3178,9 (KCLB)
9 (PubMed=16264262)
D16S53910,11
D18S5114
D21S1130,32
DXS10122
FGA23
Penta D8,9
Penta E5,8
TH016,9
TPOX8
vWA18,19,20 (PubMed=16264262)
18,19 (KCLB)

Run an STR similarity search on this cell line
Publications

PubMed=16264262; DOI=10.1038/emm.2005.48
Lee E.J., Kim J., Lee S.A., Kim E.-J., Chun Y.-C., Ryu M.H., Yook J.-I.
Characterization of newly established oral cancer cell lines derived from six squamous cell carcinoma and two mucoepidermoid carcinoma cells.
Exp. Mol. Med. 37:379-390(2005)

PubMed=17404023; DOI=10.1196/annals.1397.014
Kwak Y.E., Jeon N.K., Kim J., Lee E.J.
The cyclooxygenase-2 selective inhibitor celecoxib suppresses proliferation and invasiveness in the human oral squamous carcinoma.
Ann. N. Y. Acad. Sci. 1095:99-112(2007)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23708675; DOI=10.3892/ijo.2013.1953
Oh J.-E., Kim J.-O., Shin J.-Y., Zhang X.-H., Won H.-S., Chun S.-H., Jung C.-K., Park W.-S., Nam S.-W., Eun J.-W., Kang J.-H.
Molecular genetic characterization of p53 mutated oropharyngeal squamous cell carcinoma cells transformed with human papillomavirus E6 and E7 oncogenes.
Int. J. Oncol. 43:383-393(2013)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections KCLB; 60503
Cell line databases/resources CCLE; YD10B_UPPER_AERODIGESTIVE_TRACT
DepMap; ACH-000723
Biological sample resources BioSample; SAMN10987734
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887743
GEO; GSM888838
Other Wikidata; Q54995381
Polymorphism and mutation databases IARC_TP53; 21618
LiGeA; CCLE_770
Entry history
Entry creation06-Jun-2012
Last entry updated05-Jul-2019
Version number18