ID   GENEA020
AC   CVCL_9029
SY   GENEA020-HD; Genea020; GENEA-020; SIVF020; SIVF020-HD; SIV020; GENEAe015-A
DR   BioSamples; SAMEA104012534
DR   hPSCreg; GENEAe015-A
DR   ISCR; 1182
DR   SKIP; SKIP002918
DR   Wikidata; Q54835582
RX   PubMed=20649476;
RX   PubMed=25316320;
RX   PubMed=27346007;
RX   PubMed=35805069;
WW   https://web.archive.org/web/20180912205435/http://geneabiocells.com/services/shelf-products/human-embryonic-stem-cells/
WW   https://grants.nih.gov/stem_cells/registry/not_approved.htm
CC   From: Genea Biocells, Ltd; Sydney; Australia.
CC   Registration: NIH Human Embryonic Stem Cell Registry; not approved.
CC   Registration: UK Stem Cell Bank (UKSCB); Steering comm. appl. SCSC14-62.
CC   Sequence variation: Mutation; HGNC; 4851; HTT; Repeat_expansion; p.Gln18[48] (c.52CAG(48)) (c.52CAG[(40_?)]); ClinVar=VCV000000409; Zygosity=Unspecified (Genea).
CC   Omics: Array-based CGH.
CC   Donor information: Embryo is sibling to that giving rise to GENEA019 (Cellosaurus=CVCL_9028).
CC   Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
CC   Cell type: Embryonic stem cell; CL=CL_0002322.
ST   Source(s): PubMed=27346007
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 10,12
ST   D16S539: 11
ST   D18S51: 14,15
ST   D19S433: 13,16.2
ST   D21S11: 30,33.2
ST   D2S1338: 24
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 8
ST   D8S1179: 12,13
ST   FGA: 19,20
ST   TH01: 7,9
ST   TPOX: 8,11
ST   vWA: 14,17
DI   NCIt; C82342; Huntington's disease
DI   ORDO; Orphanet_399; Huntington disease
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Blastocyst stage
CA   Embryonic stem cell
DT   Created: 06-06-12; Last updated: 29-06-23; Version: 21
//
RX   PubMed=20649476; DOI=10.1089/scd.2010.0120;
RA   Bradley C.K., Scott H.A., Chami O., Peura T.T., Dumevska B.,
RA   Schmidt U., Stojanov T.;
RT   "Derivation of Huntington's disease-affected human embryonic stem cell
RT   lines.";
RL   Stem Cells Dev. 20:495-502(2011).
//
RX   PubMed=25316320; DOI=10.1021/pr500649m;
RA   McQuade L.R., Balachandran A., Scott H.A., Khaira S., Baker M.S.,
RA   Schmidt U.;
RT   "Proteomics of Huntington's disease-affected human embryonic stem
RT   cells reveals an evolving pathology involving mitochondrial
RT   dysfunction and metabolic disturbances.";
RL   J. Proteome Res. 13:5648-5659(2014).
//
RX   PubMed=27346007; DOI=10.1016/j.scr.2016.02.009;
RA   Dumevska B., Peura T.T., McKernan R., Goel D., Schmidt U.;
RT   "Derivation of Huntington disease affected Genea020 human embryonic
RT   stem cell line.";
RL   Stem Cell Res. 16:430-433(2016).
//
RX   PubMed=35805069; DOI=10.3390/cells11131984;
RA   Molina-Ruiz F.J., Introna C., Bombau G., Galofre M., Canals J.M.;
RT   "Standardization of cell culture conditions and routine genomic
RT   screening under a quality management system leads to reduced genomic
RT   instability in hPSCs.";
RL   Cells 11:1984.1-1984.25(2022).
//