ID   EML clone 1
AC   CVCL_9107
SY   EML C1; EML Cell Line, Clone 1; EML
DR   CLO; CLO_0002925
DR   ABM; T0679
DR   ATCC; CRL-11691
DR   Wikidata; Q54832285
RX   Patent=US5830760;
RX   PubMed=7995521;
RX   PubMed=9808058;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11691.
CC   Characteristics: KITLG dependent.
CC   Doubling time: 18-20 hours (PubMed=7995521).
CC   Transfected with: HGNC; 9864; RARA (RARalpha403; truncated version AA 1-403).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Caution: Indicated by ABM to be immortalized using SV40, this is incorrect.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
CC   Cell type: Basophil; CL=CL_0000767.
CC   Breed/subspecies: C57BL/6 x DBA/2.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Male
CA   Factor-dependent cell line
DT   Created: 06-06-12; Last updated: 30-01-24; Version: 11
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RX   Patent=US5830760;
RA   Tsai S., Collins S.J.;
RT   "Creating novel hematopoietic cell lines by expressing altered
RT   retinoic acid receptors.";
RL   Patent number US5830760, 03-Nov-1998.
//
RX   PubMed=7995521; DOI=10.1101/gad.8.23.2831;
RA   Tsai S., Bartelmez S.H., Sitnicka E., Collins S.J.;
RT   "Lymphohematopoietic progenitors immortalized by a retroviral vector
RT   harboring a dominant-negative retinoic acid receptor can recapitulate
RT   lymphoid, myeloid, and erythroid development.";
RL   Genes Dev. 8:2831-2841(1994).
//
RX   PubMed=9808058;
RA   Lawson N.D., Krause D.S., Berliner N.;
RT   "Normal neutrophil differentiation and secondary granule gene
RT   expression in the EML and MPRO cell lines.";
RL   Exp. Hematol. 26:1178-1185(1998).
//