Cell line name | 2fTGH-U3A | ||||||||||||||||||
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Synonyms | U3A | ||||||||||||||||||
Accession | CVCL_9469 | ||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: 2fTGH-U3A (RRID:CVCL_9469) | ||||||||||||||||||
Comments | Characteristics: Lacks expression of STAT1. Unresponsive to interferon-alpha and interferon-gamma (ECACC). Characteristics: 2fTGH was derived from a HPRT negative subline of HT-1080. Expression of gpt is under the control of a IFN-alpha inducible IFI6 (6-16) promoter and is thus only expressed when IFN-alpha is present in the growth medium. Transfected with: UniProtKB; P0A9M5; E.coli gpt. Transfected with: UniProtKB; P00557; E.coli hygromycin-B 4-O-kinase (hph). Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191). | ||||||||||||||||||
Sequence variations | Gene deletion; CDKN2A; Zygosity=Homozygous (from parent cell line).Heterozygous for IDH1 p.Arg132Cys (c.394C>T) (ClinVar=VCV000375891) (from parent cell line).Heterozygous for NRAS p.Gln61Lys (c.181C>A) (ClinVar=VCV000073058) (from parent cell line). | ||||||||||||||||||
Disease | Fibrosarcoma (NCIt: C3043) Fibrosarcoma (ORDO: Orphanet_2030) | ||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Parent: CVCL_0115 (2fTGH) | ||||||||||||||||||
Sex of cell | Male | ||||||||||||||||||
Age at sampling | 35Y | ||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||
STR profile | Source(s): ECACC Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||
Publications | PubMed=1837150; DOI=10.1073/pnas.88.24.11455 | ||||||||||||||||||
Cross-references | |||||||||||||||||||
Cell line collections | ECACC; 12021503
Ximbio; 151810 | ||||||||||||||||||
Other | Wikidata; Q54584476 | ||||||||||||||||||
Entry history | |||||||||||||||||||
Entry creation | 06-Jun-2012 | ||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||
Version number | 16 |