| Cell line name | 2fTGH-U3A | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Synonyms | U3A | ||||||||||||||||||
| Accession | CVCL_9469 | ||||||||||||||||||
| Resource Identification Initiative | To cite this cell line use: 2fTGH-U3A (RRID:CVCL_9469) | ||||||||||||||||||
| Comments | Characteristics: Lacks expression of STAT1. Unresponsive to interferon-alpha and interferon-gamma (ECACC). Characteristics: 2fTGH was derived from a HPRT negative subline of HT-1080. Expression of gpt is under the control of a IFN-alpha inducible IFI6 (6-16) promoter and is thus only expressed when IFN-alpha is present in the growth medium. Transfected with: UniProtKB; P0A9M5; E.coli gpt. Transfected with: UniProtKB; P00557; E.coli hygromycin-B 4-O-kinase (hph). Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191). | ||||||||||||||||||
| Sequence variations | Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).Mutation; HGNC; 5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line). | ||||||||||||||||||
| Disease | Fibrosarcoma (NCIt: C3043) Fibrosarcoma (ORDO: Orphanet_2030) | ||||||||||||||||||
| Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
| ||||||||||||||||||
| Hierarchy | Parent: CVCL_0115 (2fTGH) | ||||||||||||||||||
| Sex of cell | Male | ||||||||||||||||||
| Age at sampling | 35Y | ||||||||||||||||||
| Category | Cancer cell line | ||||||||||||||||||
| STR profile | Source(s): ECACC Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||
| Publications | PubMed=1837150; DOI=10.1073/pnas.88.24.11455 | ||||||||||||||||||
| Cross-references | |||||||||||||||||||
| Cell line collections | ECACC; 12021503
Ximbio; 151810 | ||||||||||||||||||
| Other | Wikidata; Q54584476 | ||||||||||||||||||
| Entry history | |||||||||||||||||||
| Entry creation | 06-Jun-2012 | ||||||||||||||||||
| Last entry update | 20-May-2021 | ||||||||||||||||||
| Version number | 17 | ||||||||||||||||||