ID   CLB-Ga
AC   CVCL_9529
SY   CLB-GA; CLB-GAR
DR   cancercelllines; CVCL_9529
DR   Cosmic; 1153805
DR   Cosmic; 1526623
DR   Wikidata; Q54813559
RX   DOI=10.1007/0-306-46872-7_2;
RX   PubMed=7705946;
RX   PubMed=11550280;
RX   PubMed=18534018;
RX   PubMed=18923523;
RX   PubMed=20160348;
CC   Sequence variation: Mutation; HGNC; 427; ALK; Simple; p.Arg1275Gln (c.3824G>A); ClinVar=VCV000018083; Zygosity=Heterozygous (PubMed=18923523).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   4Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 14
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RX   DOI=10.1007/0-306-46872-7_2;
RA   Thiele C.J.;
RT   "Neuroblastoma.";
RL   (In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999).
//
RX   PubMed=7705946; DOI=10.1002/ijc.2910610208;
RA   Combaret V., Turc-Carel C., Thiesse P., Rebillard A.-C., Frappaz D.,
RA   Haus O., Philip T., Favrot M.-C.;
RT   "Sensitive detection of numerical and structural aberrations of
RT   chromosome 1 in neuroblastoma by interphase fluorescence in situ
RT   hybridization. Comparison with restriction fragment length
RT   polymorphism and conventional cytogenetic analyses.";
RL   Int. J. Cancer 61:185-191(1995).
//
RX   PubMed=11550280; DOI=10.1002/gcc.1174;
RA   Van Roy N., Van Limbergen H., Vandesompele J., Van Gele M., Poppe B.,
RA   Salwen H.R., Laureys G., Manoel N., De Paepe A., Speleman F.;
RT   "Combined M-FISH and CGH analysis allows comprehensive description of
RT   genetic alterations in neuroblastoma cell lines.";
RL   Genes Chromosomes Cancer 32:126-135(2001).
//
RX   PubMed=18534018; DOI=10.1186/1476-4598-7-50;
RA   Combaret V., Boyault S., Iacono I., Brejon S., Rousseau R.,
RA   Puisieux A.;
RT   "Effect of bortezomib on human neuroblastoma: analysis of molecular
RT   mechanisms involved in cytotoxicity.";
RL   Mol. Cancer 7:50.1-50.12(2008).
//
RX   PubMed=18923523; DOI=10.1038/nature07398;
RA   Janoueix-Lerosey I., Lequin D., Brugieres L., Ribeiro A.,
RA   de Pontual L., Combaret V., Raynal V., Puisieux A., Schleiermacher G.,
RA   Pierron G., Valteau-Couanet D., Frebourg T., Michon J., Lyonnet S.,
RA   Amiel J., Delattre O.;
RT   "Somatic and germline activating mutations of the ALK kinase receptor
RT   in neuroblastoma.";
RL   Nature 455:967-970(2008).
//
RX   PubMed=20160348; DOI=10.1172/JCI41013;
RA   Bouzas-Rodriguez J., Cabrera J.R., Delloye-Bourgeois C., Ichim G.,
RA   Delcros J.-G., Raquin M.-A., Rousseau R., Combaret V., Benard J.,
RA   Tauszig-Delamasure S., Mehlen P.;
RT   "Neurotrophin-3 production promotes human neuroblastoma cell survival
RT   by inhibiting TrkC-induced apoptosis.";
RL   J. Clin. Invest. 120:850-858(2010).
//