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Cellosaurus 2474/90 (CVCL_9556)

Cell line name 2474/90
Synonyms St 2474; St2474
Accession CVCL_9556
Resource Identification Initiative To cite this cell line use: 2474/90 (RRID:CVCL_9556)
Comments Problematic cell line: Contaminated. Shown to be a HT-29 derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a 60 year old male patient gastric carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00107.
Sequence variations Heterozygous for APC p.Glu853Ter (c.2557G>T) and p.Thr1556fs*3 (c.4666_4667insA) (from parent cell line).
Heterozygous for BRAF p.Val600Glu (c.1799T>A) (from parent cell line).
Heterozygous for PIK3CA p.Pro449Thr (c.1345C>A) (from parent cell line).
Homozygous for SMAD4 p.Gln311Ter (c.931C>T) (from parent cell line).
Homozygous for TP53 p.Arg273His (c.818G>A) (from parent cell line).
Disease Rectosigmoid adenocarcinoma (NCIt: C43584)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=8100658; DOI=10.1007/BF02899281
Vollmers H.P., Stulle K., Dammrich J., Pfaff M., Papadopoulos T., Betz C., Saal K., Muller-Hermelink H.-K.
Characterization of four new gastric cancer cell lines.
Virchows Arch. B. Cell. Pathol. Incl. Mol. Pathol. 63:335-343(1993)

PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2
MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H., Drexler H.G.
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.
Int. J. Cancer 83:555-563(1999)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Biological sample resources BioSample; SAMN03151783
Other Wikidata; Q54583541