Cellosaurus MCF-7/LY2 (CVCL_9579)

Cell line name MCF-7/LY2
Synonyms LY2; LY-2
Accession CVCL_9579
Resource Identification Initiative To cite this cell line use: MCF-7/LY2 (RRID:CVCL_9579)
Comments Selected for resistance to: ChEBI; CHEBI:90187; Lilly 117018 (LY 117018).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=4029083; DOI=10.1210/endo-117-4-1409
Bronzert D.A., Greene G.L., Lippman M.E.
Selection and characterization of a breast cancer cell line resistant to the antiestrogen LY 117018.
Endocrinology 117:1409-1417(1985)

PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008
Neve R.M., Chin K., Fridlyand J., Yeh J., Baehner F.L., Fevr T., Clark L., Bayani N., Coppe J.P., Tong F., Speed T., Spellman P.T., DeVries S., Lapuk A., Wang N.J., Kuo W.L., Stilwell J.L., Pinkel D., Albertson D.G., Waldman F.M., McCormick F., Dickson R.B., Johnson M.D., Lippman M., Ethier S.P., Gazdar A.F., Gray J.W.
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer Cell 10:515-527(2006)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y., Mills G.B., Cho R.J., Collisson E.A., van't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

Cross-references
Cell line databases/resources LINCS_HMS; 51095
LINCS_LDP; LCL-2076
Lonza; 982
Ontologies EFO; EFO_0001199
Gene expression databases GEO; GSM1053705
GEO; GSM1172972
GEO; GSM1172879
Other Wikidata; Q54904374
Polymorphism and mutation databases Cosmic; 1136350