ID   MCF-7aro
AC   CVCL_9580
SY   MCF-7-Aro; MCF7aro
DR   EFO; EFO_0002072
DR   cancercelllines; CVCL_9580
DR   Wikidata; Q54904400
RX   PubMed=2208160;
RX   PubMed=9449203;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 2594; CYP19A1.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 18
//
RX   PubMed=2208160;
RA   Zhou D.-J., Pompon D., Chen S.-A.;
RT   "Stable expression of human aromatase complementary DNA in mammalian
RT   cells: a useful system for aromatase inhibitor screening.";
RL   Cancer Res. 50:6949-6954(1990).
//
RX   PubMed=9449203; DOI=10.1016/S0960-0760(97)00068-X;
RA   Sun X.-Z., Zhou D.-J., Chen S.-A.;
RT   "Autocrine and paracrine actions of breast tumor aromatase. A
RT   three-dimensional cell culture study involving aromatase transfected
RT   MCF-7 and T-47D cells.";
RL   J. Steroid Biochem. Mol. Biol. 63:29-36(1997).
//