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Cellosaurus WIBR3 (CVCL_9767)

[Text version]

Cell line name WIBR3
Synonyms WIBR 3; WIBR38; WIBRe001-A
Accession CVCL_9767
Resource Identification Initiative To cite this cell line use: WIBR3 (RRID:CVCL_9767)
Comments From: Whitehead Institute for Biomedical Research; Boston; USA.
Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-10-0079.
Registration: Swiss research registry; BAG-hES-IMP-0051.
Registration: UK Stem Cell Bank (UKSCB); Steering comm. appl. SCSC11-58.
Omics: Deep exome analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: H3K27me3 ChIP-seq epigenome analysis.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: H3K9me3 ChIP-seq epigenome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.His193Arg (c.578A>G); ClinVar=VCV000184979; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_IU05 (WIBR3 Oct4-2A-GFP )CVCL_IU04 (WIBR3 Oct4-deltaPE-GFP )
Sex of cell Female
Age at sampling Blastocyst stage
Category Embryonic stem cell
Web pages https://grants.nih.gov/stem_cells/registry/current.htm?id=419

PubMed=20471072; DOI=10.1016/j.cell.2010.04.010
Lengner C.J., Gimelbrant A.A., Erwin J.A., Cheng A.W., Guenther M.G., Welstead G.G., Alagappan R., Frampton G.M., Xu P., Muffat J., Santagata S., Powers D., Barrett C.B., Young R.A., Lee J.T., Jaenisch R., Mitalipova M.
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.
Cell 141:872-883(2010)

PubMed=24172903; DOI=10.1038/nature12745
Gafni O., Weinberger L., Mansour A.A., Manor Y.S., Chomsky E., Ben-Yosef D., Kalma Y., Viukov S., Maza I., Zviran A., Rais Y., Shipony Z., Mukamel Z., Krupalnik V., Zerbib M., Geula S., Caspi I., Schneir D., Shwartz T., Gilad S., Amann-Zalcenstein D., Benjamin S., Amit I., Tanay A., Massarwa R., Novershtern N., Hanna J.H.
Derivation of novel human ground state naive pluripotent stem cells.
Nature 504:282-286(2013)

PubMed=24936472; DOI=10.1016/j.stemcr.2014.03.014
Maetzel D., Sarkar S., Wang H., Abi-Mosleh L., Xu P., Cheng A.W., Gao Q., Mitalipova M., Jaenisch R.
Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick type C patient-specific iPS cells.
Stem Cell Reports 2:866-880(2014)

PubMed=25090446; DOI=10.1016/j.stem.2014.07.002
Theunissen T.W., Powell B.E., Wang H.-Y., Mitalipova M., Faddah D.A., Reddy J., Fan Z.-P., Maetzel D., Ganz K., Shi L.-Y., Lungjangwa T., Imsoonthornruksa S., Stelzer Y., Rangarajan S., D'Alessio A.C., Zhang J.-M., Gao Q., Dawlaty M.M., Young R.A., Gray N.S., Jaenisch R.
Systematic identification of culture conditions for induction and maintenance of naive human pluripotency.
Cell Stem Cell 15:471-487(2014)

PubMed=28445466; DOI=10.1038/nature22312
Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C., Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G., Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A., Eggan K.C.
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.
Nature 545:229-233(2017)

Cell line databases/resources hPSCreg; WIBRe001-A
ISCR; 1426
SKIP; SKIP002896
Biological sample resources BioSample; SAMN00010935
Encyclopedic resources Wikidata; Q54994042
Gene expression databases GEO; GSM523600
GEO; GSM523601
GEO; GSM529410
GEO; GSM529413
GEO; GSM529416
GEO; GSM529419
GEO; GSM1272761
GEO; GSM1272762
GEO; GSM1272763
GEO; GSM1272764
GEO; GSM1272765
GEO; GSM1272766
GEO; GSM1272767
GEO; GSM1272768
GEO; GSM1272769
GEO; GSM1272770
GEO; GSM1272771
GEO; GSM1272772
GEO; GSM1564930
GEO; GSM1564931
GEO; GSM1564932
Entry history
Entry creation06-Jun-2012
Last entry update20-May-2021
Version number17