ID   WIBR3
AC   CVCL_9767
SY   WIBR 3; WIBR38; WIBRe001-A
DR   BioSample; SAMN00010935
DR   GEO; GSM523600
DR   GEO; GSM523601
DR   GEO; GSM529410
DR   GEO; GSM529413
DR   GEO; GSM529416
DR   GEO; GSM529419
DR   GEO; GSM1272761
DR   GEO; GSM1272762
DR   GEO; GSM1272763
DR   GEO; GSM1272764
DR   GEO; GSM1272765
DR   GEO; GSM1272766
DR   GEO; GSM1272767
DR   GEO; GSM1272768
DR   GEO; GSM1272769
DR   GEO; GSM1272770
DR   GEO; GSM1272771
DR   GEO; GSM1272772
DR   GEO; GSM1564930
DR   GEO; GSM1564931
DR   GEO; GSM1564932
DR   hPSCreg; WIBRe001-A
DR   ISCR; 1426
DR   NIHhESC; NIHhESC-10-0079
DR   SKIP; SKIP002896
DR   Wikidata; Q54994042
RX   PubMed=20471072;
RX   PubMed=24172903;
RX   PubMed=24936472;
RX   PubMed=25090446;
RX   PubMed=28445466;
CC   From: Whitehead Institute for Biomedical Research; Boston; USA.
CC   Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-10-0079.
CC   Registration: Swiss research registry; BAG-hES-IMP-0051.
CC   Registration: UK Stem Cell Bank (UKSCB); Steering comm. appl. SCSC11-58.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.His193Arg (c.578A>G); ClinVar=VCV000184979; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
CC   Omics: Deep exome analysis.
CC   Omics: H3K27ac ChIP-seq epigenome analysis.
CC   Omics: H3K27me3 ChIP-seq epigenome analysis.
CC   Omics: H3K4me1 ChIP-seq epigenome analysis.
CC   Omics: H3K4me3 ChIP-seq epigenome analysis.
CC   Omics: H3K9me3 ChIP-seq epigenome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
CC   Cell type: Embryonic stem cell; CL=CL_0002322.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Blastocyst stage
CA   Embryonic stem cell
DT   Created: 06-06-12; Last updated: 29-06-23; Version: 19
//
RX   PubMed=20471072; DOI=10.1016/j.cell.2010.04.010;
RA   Lengner C.J., Gimelbrant A.A., Erwin J.A., Cheng A.W., Guenther M.G.,
RA   Welstead G.G., Alagappan R., Frampton G.M., Xu P., Muffat J.,
RA   Santagata S., Powers D., Barrett C.B., Young R.A., Lee J.T.,
RA   Jaenisch R., Mitalipova M.;
RT   "Derivation of pre-X inactivation human embryonic stem cells under
RT   physiological oxygen concentrations.";
RL   Cell 141:872-883(2010).
//
RX   PubMed=24172903; DOI=10.1038/nature12745;
RA   Gafni O., Weinberger L., Mansour A.A., Manor Y.S., Chomsky E.,
RA   Ben-Yosef D., Kalma Y., Viukov S., Maza I., Zviran A., Rais Y.,
RA   Shipony Z., Mukamel Z., Krupalnik V., Zerbib M., Geula S., Caspi I.,
RA   Schneir D., Shwartz T., Gilad S., Amann-Zalcenstein D., Benjamin S.,
RA   Amit I., Tanay A., Massarwa R., Novershtern N., Hanna J.H.;
RT   "Derivation of novel human ground state naive pluripotent stem
RT   cells.";
RL   Nature 504:282-286(2013).
//
RX   PubMed=24936472; DOI=10.1016/j.stemcr.2014.03.014;
RA   Maetzel D., Sarkar S., Wang H., Abi-Mosleh L., Xu P., Cheng A.W.,
RA   Gao Q., Mitalipova M., Jaenisch R.;
RT   "Genetic and chemical correction of cholesterol accumulation and
RT   impaired autophagy in hepatic and neural cells derived from
RT   Niemann-Pick type C patient-specific iPS cells.";
RL   Stem Cell Reports 2:866-880(2014).
//
RX   PubMed=25090446; DOI=10.1016/j.stem.2014.07.002;
RA   Theunissen T.W., Powell B.E., Wang H.-Y., Mitalipova M., Faddah D.A.,
RA   Reddy J., Fan Z.-P., Maetzel D., Ganz K., Shi L.-Y., Lungjangwa T.,
RA   Imsoonthornruksa S., Stelzer Y., Rangarajan S., D'Alessio A.C.,
RA   Zhang J.-M., Gao Q., Dawlaty M.M., Young R.A., Gray N.S., Jaenisch R.;
RT   "Systematic identification of culture conditions for induction and
RT   maintenance of naive human pluripotency.";
RL   Cell Stem Cell 15:471-487(2014).
//
RX   PubMed=28445466; DOI=10.1038/nature22312;
RA   Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C.,
RA   Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G.,
RA   Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A.,
RA   Eggan K.C.;
RT   "Human pluripotent stem cells recurrently acquire and expand dominant
RT   negative P53 mutations.";
RL   Nature 545:229-233(2017).
//