ID   WA14
AC   CVCL_9775
SY   WA 14; H14; GE14; WAe005-A; WICELLe005-A; WAe014-A
DR   BioSample; SAMN03471899
DR   GEO; GSM347925
DR   GEO; GSM856733
DR   hPSCreg; WAe014-A
DR   ISCR; 93
DR   SKIP; SKIP001937
DR   WiCell; wa14
DR   WiCell; wa14-cgmp-material
DR   WiCell; wa14-matched-research
DR   Wikidata; Q54993517
RX   PubMed=9804556;
RX   PubMed=14745950;
RX   PubMed=16388305;
RX   PubMed=17570852;
RX   PubMed=17572666;
RX   PubMed=21983960;
RX   PubMed=23117585;
RX   PubMed=28445466;
RX   PubMed=30388422;
WW   https://grants.nih.gov/stem_cells/registry/current.htm?id=416
WW   https://stemcelldb.nih.gov/cellLineDetails.do?id=29
WW   http://news.wisc.edu/nih-reapproves-wicells-h9-and-three-other-wisconsin-stem-cell-lines-for-federally-funded-research/
CC   Group: Clinical grade hESC cell line.
CC   From: University of Wisconsin; Madison; USA.
CC   Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-10-0064.
CC   Registration: Swiss research registry; BAG-hES-IMP-0033.
CC   Registration: UK Stem Cell Bank (UKSCB); Steering comm. appl. SCSC06-18/SCSC11-18.
CC   Omics: Deep exome analysis.
CC   Omics: Deep phosphoproteome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Anecdotal: WA01, WA07, WA09, WA13 and WA14 were the first human embryonic stem cells to be established.
CC   Miscellaneous: Sibling to WA07 (CVCL_9772) and WA13 (CVCL_9774).
ST   Source(s): WiCell
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 11,13
ST   D18S51: 12,14
ST   D21S11: 30,31
ST   D3S1358: 15,16
ST   D5S818: 11,13
ST   D7S820: 10,11
ST   D8S1179: 13,14
ST   FGA: 21
ST   Penta D: 12,13
ST   Penta E: 13,20
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 15,16
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   Blastocyst stage
CA   Embryonic stem cell
DT   Created: 06-06-12; Last updated: 13-11-18; Version: 21
//
RX   PubMed=9804556; DOI=10.1126/science.282.5391.1145;
RA   Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., Waknitz M.A.,
RA   Swiergiel J.J., Marshall V.S., Jones J.M.;
RT   "Embryonic stem cell lines derived from human blastocysts.";
RL   Science 282:1145-1147(1998).
//
RX   PubMed=14745950; DOI=10.1002/dvdy.10431;
RA   Carpenter M.K., Rosler E.S., Fisk G.J., Brandenberger R., Ares X.,
RA   Miura T., Lucero M., Rao M.S.;
RT   "Properties of four human embryonic stem cell lines maintained in a
RT   feeder-free culture system.";
RL   Dev. Dyn. 229:243-258(2004).
//
RX   PubMed=16388305; DOI=10.1038/nbt1177;
RA   Ludwig T.E., Levenstein M.E., Jones J.M., Berggren W.T., Mitchen E.R.,
RA   Frane J.L., Crandall L.J., Daigh C.A., Conard K.R., Piekarczyk M.S.,
RA   Llanas R.A., Thomson J.A.;
RT   "Derivation of human embryonic stem cells in defined conditions.";
RL   Nat. Biotechnol. 24:185-187(2006).
//
RX   PubMed=17570852; DOI=10.1186/gb-2007-8-6-r113;
RA   Hirst M., Delaney A., Rogers S.A., Schnerch A., Persaud D.R.,
RA   O'Connor M.D., Zeng T., Moksa M., Fichter K., Mah D., Go A.,
RA   Morin R.D., Baross A., Zhao Y., Khattra J., Prabhu A.-L., Pandoh P.,
RA   McDonald H., Asano J., Dhalla N., Ma K., Lee S., Ally A., Chahal N.,
RA   Menzies S., Siddiqui A., Holt R., Jones S., Gerhard D.S.,
RA   Thomson J.A., Eaves C.J., Marra M.A.;
RT   "LongSAGE profiling of nine human embryonic stem cell lines.";
RL   Genome Biol. 8:R113.1-R113.12(2007).
//
RX   PubMed=17572666; DOI=10.1038/nbt1318;
RA   Adewumi O., Aflatoonian B., Ahrlund-Richter L., Amit M., Andrews P.W.,
RA   Beighton G., Bello P.A., Benvenisty N., Berry L.S., Bevan S., Blum B.,
RA   Brooking J., Chen K.G., Choo A.B.H., Churchill G.A., Corbel M.,
RA   Damjanov I., Draper J.S., Dvorak P., Emanuelsson K., Fleck R.A.,
RA   Ford A., Gertow K., Gertsenstein M., Gokhale P.J., Hamilton R.S.,
RA   Hampl A., Healy L.E., Hovatta O., Hyllner J., Imreh M.P.,
RA   Itskovitz-Eldor J., Jackson J., Johnson J.L., Jones M., Kee K.,
RA   King B.L., Knowles B.B., Lako M., Lebrin F., Mallon B.S., Manning D.,
RA   Mayshar Y., McKay R.D.G., Michalska A.E., Mikkola M., Mileikovsky M.,
RA   Minger S.L., Moore H.D., Mummery C.L., Nagy A., Nakatsuji N.,
RA   O'Brien C.M., Oh S.K.W., Olsson C., Otonkoski T., Park K.-Y.,
RA   Passier R., Patel H., Patel M., Pedersen R., Pera M.F.,
RA   Piekarczyk M.S., Pera R.A.R., Reubinoff B.E., Robins A.J., Rossant J.,
RA   Rugg-Gunn P., Schulz T.C., Semb H., Sherrer E.S., Siemen H.,
RA   Stacey G.N., Stojkovic M., Suemori H., Szatkiewicz J., Turetsky T.,
RA   Tuuri T., van den Brink S., Vintersten K., Vuoristo S., Ward D.,
RA   Weaver T.A., Young L.A., Zhang W.;
RT   "Characterization of human embryonic stem cell lines by the
RT   International Stem Cell Initiative.";
RL   Nat. Biotechnol. 25:803-816(2007).
//
RX   PubMed=21983960; DOI=10.1038/nmeth.1699;
RA   Phanstiel D.H., Brumbaugh J., Wenger C.D., Tian S., Probasco M.D.,
RA   Bailey D.J., Swaney D.L., Tervo M.A., Bolin J.M., Ruotti V.,
RA   Stewart R., Thomson J.A., Coon J.J.;
RT   "Proteomic and phosphoproteomic comparison of human ES and iPS
RT   cells.";
RL   Nat. Methods 8:821-827(2011).
//
RX   PubMed=23117585; DOI=10.1016/j.scr.2012.09.002;
RA   Mallon B.S., Chenoweth J.G., Johnson K.R., Hamilton R.S., Tesar P.J.,
RA   Yavatkar A.S., Tyson L.J., Park K., Chen K.G., Fann Y.C., McKay R.D.G.;
RT   "StemCellDB: the human pluripotent stem cell database at the National
RT   Institutes of Health.";
RL   Stem Cell Res. 10:57-66(2013).
//
RX   PubMed=28445466; DOI=10.1038/nature22312;
RA   Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C.,
RA   Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G.,
RA   Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A.,
RA   Eggan K.;
RT   "Human pluripotent stem cells recurrently acquire and expand dominant
RT   negative P53 mutations.";
RL   Nature 545:229-233(2017).
//
RX   PubMed=30388422; DOI=10.1016/j.stem.2018.10.009;
RA   Ludwig T.E., Kujak A., Rauti A., Andrzejewski S., Langbehn S.,
RA   Mayfield J., Fuller J., Yashiro Y., Hara Y., Bhattacharyya A.;
RT   "20 years of human pluripotent stem cell research: it all started with
RT   five lines.";
RL   Cell Stem Cell 23:644-648(2018).
//