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Cellosaurus SZ95 (CVCL_9803)

Cell line name SZ95
Synonyms SZ-95; SZ 95
Accession CVCL_9803
Resource Identification Initiative To cite this cell line use: SZ95 (RRID:CVCL_9803)
Comments Group: Patented cell line.
Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2383.
Doubling time: 52.4 +- 1.6 hours (PubMed=10594745).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Face, skin, sebaceous gland; UBERON=UBERON_0003487.
Cell type: Sebocyte; CL=CL_0000317.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 87Y
Category Transformed cell line
Publications

PubMed=10594745; DOI=10.1046/j.1523-1747.1999.00771.x
Zouboulis C.C., Seltmann H., Neitzel H., Orfanos C.E.
Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95).
J. Invest. Dermatol. 113:1011-1020(1999)

PubMed=18308950; DOI=10.1634/stemcells.2007-0651
Lo Celso C., Berta M.A., Braun K.M., Frye M., Lyle S., Zouboulis C.C., Watt F.M.
Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin.
Stem Cells 26:1241-1252(2008)

PubMed=18690467; DOI=10.1007/s00403-008-0879-5
Zouboulis C.C., Schagen S., Alestas T.
The sebocyte culture: a model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne.
Arch. Dermatol. Res. 300:397-413(2008)

PubMed=20224690; DOI=10.4161/derm.1.2.8736
Xia L., Zouboulis C.C., Ju Q.
Culture of human sebocytes in vitro.
Dermato-Endocrinol. 1:92-95(2009)

PubMed=25061872; DOI=10.1172/JCI64628
Olah A., Toth B.I., Borbiro I., Sugawara K., Szollosi A.G., Czifra G., Pal B., Ambrus L., Kloepper J., Camera E., Ludovici M., Picardo M., Voets T., Zouboulis C.C., Paus R., Biro T.
Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes.
J. Clin. Invest. 124:3713-3724(2014)

PubMed=25828468; DOI=10.1111/exd.12712
Nikolakis G., Seltmann H., Hossini A.M., Makrantonaki E., Knolle J., Zouboulis C.C.
Ex vivo human skin and SZ95 sebocytes exhibit a homoeostatic interaction in a novel coculture contact model.
Exp. Dermatol. 24:497-502(2015)

Patent=US20160237406
Zouboulis C.C.
Sebocytes, sebocyte cell lines and applications thereof.
Patent number US20160237406, 18-Aug-2016

PubMed=29451719; DOI=10.1111/exd.13513
Schneider M.R., Zouboulis C.C.
Primary sebocytes and sebaceous gland cell lines for studying sebaceous lipogenesis and sebaceous gland diseases.
Exp. Dermatol. 27:484-488(2018)

PubMed=29927962; DOI=10.1371/journal.pone.0198323
Torocsik D., Kovacs D., Poliska S., Szentkereszty-Kovacs Z., Lovaszi M., Hegyi K., Szegedi A., Zouboulis C.C., Stahle M.
Genome wide analysis of TLR1/2- and TLR4-activated SZ95 sebocytes reveals a complex immune-competence and identifies serum amyloid A as a marker for activated sebaceous glands.
PLoS ONE 13:E0198323-E0198323(2018)

Cross-references
Cell line databases/resources FCS-free; 31-2-33-2-4-3
Lonza; 489
Anatomy/cell type resources BTO; BTO:0003484
Encyclopedic resources Wikidata; Q54971318
Gene expression databases GEO; GSE57571
Entry history
Entry creation06-Jun-2012
Last entry update29-Jun-2023
Version number14