ID   WB-F344
AC   CVCL_9806
SY   WB F344; WBF344
DR   BTO; BTO:0004318
DR   EFO; EFO_0002871
DR   CLS; 305201
DR   JCRB; JCRB0193
DR   Millipore; SCC253
DR   Wikidata; Q54993590
RX   PubMed=6468534;
RX   PubMed=9745712;
RX   PubMed=9846981;
RX   PubMed=20140209;
CC   Group: Space-flown cell line (cellonaut).
CC   Characteristics: Well-established and versatile model for studies of liver cell renewal, differentiation, and origination of hepatic cancers. Expresses markers of liver progenitor cells, including EpCAM, Thy1, and Afp (Millipore=SCC253).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Cell type: Epithelial cell; CL=CL_0000066.
CC   Breed/subspecies: Fischer 344.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 06-06-12; Last updated: 29-06-23; Version: 15
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RX   PubMed=6468534; DOI=10.1016/0014-4827(84)90666-9;
RA   Tsao M.-S., Smith J.D., Nelson K.G., Grisham J.W.;
RT   "A diploid epithelial cell line from normal adult rat liver with
RT   phenotypic properties of 'oval' cells.";
RL   Exp. Cell Res. 154:38-52(1984).
//
RX   PubMed=9745712; DOI=10.1111/j.1432-0436.1998.00215.x;
RA   Zvibel I., Fiorino A.S., Brill S., Reid L.M.;
RT   "Phenotypic characterization of rat hepatoma cell lines and
RT   lineage-specific regulation of gene expression by differentiation
RT   agents.";
RL   Differentiation 63:215-223(1998).
//
RX   PubMed=9846981; DOI=10.1016/S0002-9440(10)65705-7;
RA   Hooth M.J., Coleman W.B., Presnell S.C., Borchert K.M., Grisham J.W.,
RA   Smith G.J.;
RT   "Spontaneous neoplastic transformation of WB-F344 rat liver epithelial
RT   cells.";
RL   Am. J. Pathol. 153:1913-1921(1998).
//
RX   PubMed=20140209; DOI=10.1371/journal.pone.0009084;
RA   Jimenez R.H., Lee J.-S., Francesconi M., Castellani G., Neretti N.,
RA   Sanders J.A., Sedivy J.M., Gruppuso P.A.;
RT   "Regulation of gene expression in hepatic cells by the mammalian
RT   Target of Rapamycin (mTOR).";
RL   PLoS ONE 5:E9084-E9084(2010).
//