| Cell line name |
Tet21N |
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| Synonyms |
TET21/N; Tet21/N; Tet-21/N; SHEP-21/N; SHEP-21N; SHEP21N |
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| Accession |
CVCL_9812 |
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| Resource Identification Initiative |
To cite this cell line use: Tet21N (RRID:CVCL_9812) |
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| Comments |
Population: Caucasian.
Transfected with: HGNC; 7559; MYCN.
Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371. |
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| Sequence variations |
- Mutation; HGNC; 427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_2A38 (SHEP-SF) |
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| Sex of cell |
Female |
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| Age at sampling |
4Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=8761302
Lutz W., Stohr M., Schurmann J., Wenzel A., Lohr A., Schwab M.
Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.
Oncogene 13:803-812(1996) PubMed=17506115; DOI=10.1002/nbm.1181
Peet A.C., McConville C.M., Wilson M.P., Levine B.A., Reed M., Dyer S.A., Edwards E.C., Strachan M.C., McMullan D.J., Wilkes T.M., Grundy R.G.
1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines.
NMR Biomed. 20:692-700(2007) PubMed=22213050; DOI=10.1002/ijc.27415
Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_9812
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| Anatomy/cell type resources |
BTO; BTO:0004654
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| Encyclopedic resources |
Wikidata; Q54972195
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| Gene expression databases |
GEO; GSM692858
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| Entry history |
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| Entry creation | 06-Jun-2012 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 20 |
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