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Cellosaurus Okajima (CVCL_9815)

[Text version]
Cell line name Okajima
Synonyms OKAJIMA
Accession CVCL_9815
Resource Identification Initiative To cite this cell line use: Okajima (RRID:CVCL_9815)
Comments Population: Japanese.
Doubling time: 36-40 hours (PubMed=3962675); 36-38 hours (CelloPub=CLPUB00584).
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Misspelling: Okajama; IARC_TP53=999.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg342Ter (c.1024C>T); ClinVar=VCV000182970; Zygosity=Homozygous (PubMed=1933850).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*11:01,31:01
HLA-BB*15:27,51:01
HLA-CC*03:03,15:02
Class II
HLA-DRDRB1*11:16,14:121
Disease Gastric undifferentiated carcinoma (NCIt: C5476)
Undifferentiated carcinoma of stomach (ORDO: Orphanet_423786)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 38Y
Category Cancer cell line
STR profile Source(s): PubMed=25877200

Markers:
AmelogeninX
CSF1PO11,12
D2S133817,24
D3S135817,18
D5S81811
D7S8208,12
D8S117914,15
D13S3179
D16S5399,11
D18S5115,18
D19S43314.2
D21S1129,30
FGA19,25
Penta D9,12
Penta E17,21
TH018
TPOX8
vWA14

Run an STR similarity search on this cell line
Publications

CLPUB00584
Motoyama T., Hojo H., Suzuki T., Oboshi S.
Evaluation of the regrowth assay method as an in vitro drug sensitivity test and its application to cultured human gastric cancer cell lines.
Acta Med. Biol. 27:49-63(1979)

PubMed=6862145; DOI=10.20772/cancersci1959.74.2_240
Naito S., Inoue S., Kinjo M., Tanaka K.
Thromboplastic and fibrinolytic activities of cultured human gastric cancer cell lines.
Gann 74:240-247(1983)

PubMed=3962675; DOI=10.1111/j.1440-1827.1986.tb01461.x
Motoyama T., Hojo H., Watanabe H.
Comparison of seven cell lines derived from human gastric carcinomas.
Acta Pathol. Jpn. 36:65-83(1986)

PubMed=1933850
Yamada Y., Yoshida T., Hayashi K., Sekiya T., Yokota J., Hirohashi S., Nakatani K., Nakano H., Sugimura T., Terada M.
p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.
Cancer Res. 51:5800-5805(1991)

PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x
Takada H., Imoto I., Tsuda H., Sonoda I., Ichikura T., Mochizuki H., Okanoue T., Inazawa J.
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
Cancer Sci. 96:100-110(2005)

PubMed=17505008; DOI=10.1158/1078-0432.CCR-06-2743
Takeda M., Arao T., Yokote H., Komatsu T., Yanagihara K., Sasaki H., Yamada Y., Tamura T., Fukuoka K., Kimura H., Saijo N., Nishio K.
AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor.
Clin. Cancer Res. 13:3051-3057(2007)

PubMed=24807215; DOI=10.1038/ncomms4830
Liu J.-F., McCleland M.L., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H.-B., Wan Y.-N., Chopra V.S., Yaylaoglu M.B., Yuan W.-L., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.-M.
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830.1-3830.8(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9815
CGH-DB; 123-1
CGH-DB; 9025-4
Biological sample resources BioSample; SAMN03470905
Chemistry resources PharmacoDB; Okajima_1198_2019
Encyclopedic resources Wikidata; Q54931911
Experimental variables resources EFO; EFO_0006715
Gene expression databases ArrayExpress; E-MTAB-2706
Polymorphism and mutation databases Cosmic; 926117
Cosmic; 1001656
Cosmic; 1518258
Cosmic; 2443795
IARC_TP53; 999
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number23