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Cellosaurus ZK-58 (CVCL_9920)

Cell line name ZK-58
Synonyms ZK58; HOS 58
Accession CVCL_9920
Resource Identification Initiative To cite this cell line use: ZK-58 (RRID:CVCL_9920)
Comments Characteristics: Established from a nude mice xenograft (PubMed=9674117).
Doubling time: ~72 hours (PubMed=21519327).
Omics: SNP array analysis.
Derived from site: In situ; Bone, leg; UBERON=UBERON_0005893.
Sequence variations
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=19787792).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 21Y
Category Cancer cell line
STR profile Source(s): PubMed=19787792

Markers:
AmelogeninX,Y
D2S133825
D3S135816
D5S81811
D8S117913,14
D16S53911
D18S5115,18
D19S43312,14
D21S1129,30.2
FGA24
SE3324.2
TH016
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=9674117; DOI=10.1046/j.1432-0436.1998.6320081.x
Siggelkow H., Niedhart C., Kurre W., Ihbe A., Schulz A., Atkinson M.J., Hufner M.
In vitro differentiation potential of a new human osteosarcoma cell line (HOS 58).
Differentiation 63:81-91(1998)

PubMed=12645653; DOI=10.1016/S0165-4608(02)00685-4
Ozaki T., Neumann T., Wai D.H., Schaefer K.-L., van Valen F., Lindner N., Scheel C., Boecker W., Winkelmann W., Dockhorn-Dworniczak B., Horst J., Poremba C.
Chromosomal alterations in osteosarcoma cell lines revealed by comparative genomic hybridization and multicolor karyotyping.
Cancer Genet. Cytogenet. 140:145-152(2003)

PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809
Schaefer K.-L., Brachwitz K., Wai D.H., Braun Y., Diallo R., Korsching E., Eisenacher M., Voss R., van Valen F., Baer C., Selle B., Spahn L., Liao S.-K., Lee K.A.W., Hogendoorn P.C.W., Reifenberger G., Gabbert H.E., Poremba C.
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Cancer Res. 64:3395-3405(2004)

PubMed=19787792; DOI=10.1002/gcc.20717
Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S.E., Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H., Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W., Buerger H., Aigner T., Gabbert H.E., Poremba C.
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=21519327; DOI=10.1038/labinvest.2011.72
Mohseny A.B., Machado I., Cai Y.-P., Schaefer K.-L., Serra M., Hogendoorn P.C.W., Llombart-Bosch A., Cleton-Jansen A.-M.
Functional characterization of osteosarcoma cell lines provides representative models to study the human disease.
Lab. Invest. 91:1195-1205(2011)

PubMed=23144859; DOI=10.1371/journal.pone.0048262
Kresse S.H., Rydbeck H., Skarn M., Namlos H.M., Barragan-Polania A.H., Cleton-Jansen A.-M., Serra M., Liestol K., Hogendoorn P.C.W., Hovig E., Myklebost O., Meza-Zepeda L.A.
Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma.
PLoS ONE 7:E48262-E48262(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9920
Encyclopedic resources Wikidata; Q54995932
Gene expression databases GEO; GSM879224
Polymorphism and mutation databases Cosmic; 1529906
IARC_TP53; 27033
Progenetix; CVCL_9920
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number16