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Cellosaurus NCI-H684 (CVCL_9980)

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Cell line name NCI-H684
Synonyms H684; H-684; NCIH684
Accession CVCL_9980
Resource Identification Initiative To cite this cell line use: NCI-H684 (RRID:CVCL_9980)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for KRAS p.Gly12Asp (c.35G>A) (CCLE).
Homozygous for TP53 p.Gly245Ser (c.733G>A) (CCLE).
Disease Colon adenocarcinoma (NCIt: C4349)
Derived from metastatic site: Liver.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): KCLB; PubMed=25926053

D13S3178,12 (KCLB)
12 (PubMed=25926053)
TH019,9.3 (KCLB)
9 (PubMed=25926053)

Run an STR similarity search on this cell line

Park J.-G., Oie H.K., Sugarbaker P.H., Henslee J.G., Chen T.-R., Johnson B.E., Gazdar A.F.
Characteristics of cell lines established from human colorectal carcinoma.
Cancer Res. 47:6710-6718(1987)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002-7002(2015)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cell line collections KCLB; 90684
Cell line databases/resources CCLE; NCIH684_LIVER
DepMap; ACH-000089
Biological sample resources BioSample; SAMN10988095
Chemistry resources PharmacoDB; NCIH684_1128_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM1448215
Other Wikidata; Q54908102
Polymorphism and mutation databases IARC_TP53; 28309
LiGeA; CCLE_151
Entry history
Entry creation06-Jun-2012
Last entry updated06-Sep-2019
Version number12