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Cellosaurus IOR/SARG (CVCL_9995)

[Text version]
Cell line name IOR/SARG
Synonyms IOR-SARG; SARG
Accession CVCL_9995
Resource Identification Initiative To cite this cell line use: IOR/SARG (RRID:CVCL_9995)
Comments From: Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli; Bologna; Italy.
Doubling time: 58 +- 4 hours (PubMed=1622859); ~72 hours (PubMed=21519327).
Omics: SNP array analysis.
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Hemizygous (PubMed=19787792).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr205Ter (c.615T>A); ClinVar=VCV000185498; Zygosity=Unspecified (PubMed=19787792).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 25Y
Category Cancer cell line
STR profile Source(s): PubMed=19787792

Markers:
AmelogeninX,Y
D2S133817
D3S135814
D5S81811,12
D8S117913
D16S53911
D18S5112,15
D19S43314
D21S1129,30.2
FGA21
SE3323.2
TH016,9.3
TPOX8,11
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=1622859; DOI=10.1093/annonc/3.suppl_2.S29
Scotlandi K., Serra M., Landuzzi L., Baldini N.
SARG: a new human osteosarcoma cell line. Expression of bone markers and of major histocompatibility antigens.
Ann. Oncol. 3 Suppl. 2:S29-S31(1992)

PubMed=8617485; DOI=10.1016/S0046-8177(96)90115-X
Scotlandi K., Serra M., Manara M.C., Benini S., Sarti M., Maurici D., Lollini P.-L., Picci P., Bertoni F., Baldini N.
Immunostaining of the p30/32MIC2 antigen and molecular detection of EWS rearrangements for the diagnosis of Ewing's sarcoma and peripheral neuroectodermal tumor.
Hum. Pathol. 27:408-416(1996)

PubMed=9935160; DOI=10.1002/(SICI)1097-0215(19990209)80:4<581::AID-IJC16>3.0.CO;2-O
Benini S., Baldini N., Manara M.C., Chano T., Serra M., Rizzi S., Lollini P.-L., Picci P., Scotlandi K.
Redundancy of autocrine loops in human osteosarcoma cells.
Int. J. Cancer 80:581-588(1999)

PubMed=19787792; DOI=10.1002/gcc.20717
Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S.E., Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H., Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W., Buerger H., Aigner T., Gabbert H.E., Poremba C.
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=21519327; DOI=10.1038/labinvest.2011.72
Mohseny A.B., Machado I., Cai Y.-P., Schaefer K.-L., Serra M., Hogendoorn P.C.W., Llombart-Bosch A., Cleton-Jansen A.-M.
Functional characterization of osteosarcoma cell lines provides representative models to study the human disease.
Lab. Invest. 91:1195-1205(2011)

PubMed=23144859; DOI=10.1371/journal.pone.0048262
Kresse S.H., Rydbeck H., Skarn M., Namlos H.M., Barragan-Polania A.H., Cleton-Jansen A.-M., Serra M., Liestol K., Hogendoorn P.C.W., Hovig E., Myklebost O., Meza-Zepeda L.A.
Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma.
PLoS ONE 7:E48262-E48262(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9995
Encyclopedic resources Wikidata; Q54897879
Gene expression databases GEO; GSM879215
Polymorphism and mutation databases Cosmic; 1082494
Cosmic; 1529897
IARC_TP53; 27029
Progenetix; CVCL_9995
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number22