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Cellosaurus MDA-MB-231-5a (CVCL_9U30)

[Text version]

Cell line name MDA-MB-231-5a
Synonyms MDA-5a
Accession CVCL_9U30
Resource Identification Initiative To cite this cell line use: MDA-MB-231-5a (RRID:CVCL_9U30)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Sequence variations Heterozygous for BRAF p.Gly464Val (c.1391G>T) (ClinVar=VCV000040364) (from parent cell line).
Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (ClinVar=VCV000012580) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Homozygous for TP53 p.Arg280Lys (c.839G>A) (ClinVar=VCV000376657) (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
CVCL_9U31 (MDA-MB-231-5a-D)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line

Saito H., Tsunenari T., Onuma E., Sato K., Ogata E., Yamada-Okabe H.
Humanized monoclonal antibody against parathyroid hormone-related protein suppresses osteolytic bone metastasis of human breast cancer cells derived from MDA-MB-231.
Anticancer Res. 25:3817-3823(2005)

PubMed=17129361; DOI=10.1111/j.1349-7006.2006.00357.x
Ehata S., Hanyu A., Fujime M., Katsuno Y., Fukunaga E., Goto K., Ishikawa Y., Nomura K., Yokoo H., Shimizu T., Ogata E., Miyazono K., Shimizu K., Imamura T.
Ki26894, a novel transforming growth factor-beta type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line.
Cancer Sci. 98:127-133(2007)

Other Wikidata; Q54904592
Entry history
Entry creation23-Feb-2016
Last entry update02-Jul-2020
Version number9