ID   MDA-MB-231-5a-D
AC   CVCL_9U31
SY   MDA-231-D
DR   cancercelllines; CVCL_9U31
DR   Wikidata; Q54904593
RX   PubMed=17129361;
RX   PubMed=18663362;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_9U30 ! MDA-MB-231-5a
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 23-02-16; Last updated: 05-10-23; Version: 17
//
RX   PubMed=17129361; DOI=10.1111/j.1349-7006.2006.00357.x;
RA   Ehata S., Hanyu A., Fujime M., Katsuno Y., Fukunaga E., Goto K.,
RA   Ishikawa Y., Nomura K., Yokoo H., Shimizu T., Ogata E., Miyazono K.,
RA   Shimizu K., Imamura T.;
RT   "Ki26894, a novel transforming growth factor-beta type I receptor
RT   kinase inhibitor, inhibits in vitro invasion and in vivo bone
RT   metastasis of a human breast cancer cell line.";
RL   Cancer Sci. 98:127-133(2007).
//
RX   PubMed=18663362; DOI=10.1038/onc.2008.232;
RA   Katsuno Y., Hanyu A., Kanda H., Ishikawa Y., Akiyama F., Iwase T.,
RA   Ogata E., Ehata S., Miyazono K., Imamura T.;
RT   "Bone morphogenetic protein signaling enhances invasion and bone
RT   metastasis of breast cancer cells through Smad pathway.";
RL   Oncogene 27:6322-6333(2008).
//