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Cellosaurus MDA-MB-231-5a-D-TbetaFluc/Rluc (CVCL_9U32)

[Text version]

Cell line name MDA-MB-231-5a-D-TbetaFluc/Rluc
Synonyms MDA-231-D-TbetaFluc/Rluc; MDA-D-TbetaFluc/Rluc; 5a-D-Luc
Accession CVCL_9U32
Resource Identification Initiative To cite this cell line use: MDA-MB-231-5a-D-TbetaFluc/Rluc (RRID:CVCL_9U32)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; P27652; Renilla-type luciferase.
Sequence variations Heterozygous for BRAF p.Gly464Val (c.1391G>T) (from parent cell line).
Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Homozygous for TP53 p.Arg280Lys (c.839G>A) (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9U31 (MDA-MB-231-5a-D)
Children:
CVCL_9U33 (MDA-MB-231-5a-D-TbetaFluc/Rluc-ZsGreen)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=17129361; DOI=10.1111/j.1349-7006.2006.00357.x
Ehata S., Hanyu A., Fujime M., Katsuno Y., Fukunaga E., Goto K., Ishikawa Y., Nomura K., Yokoo H., Shimizu T., Ogata E., Miyazono K., Shimizu K., Imamura T.
Ki26894, a novel transforming growth factor-beta type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line.
Cancer Sci. 98:127-133(2007)

PubMed=18663362; DOI=10.1038/onc.2008.232
Katsuno Y., Hanyu A., Kanda H., Ishikawa Y., Akiyama F., Iwase T., Ogata E., Ehata S., Miyazono K., Imamura T.
Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway.
Oncogene 27:6322-6333(2008)

PubMed=26691676; DOI=10.3892/ijo.2015.3300
Sudo H., Tsuji A.B., Sugyo A., Takuwa H., Masamoto K., Tomita Y., Suzuki N., Imamura T., Koizumi M., Saga T.
Establishment and evaluation of a new highly metastatic tumor cell line 5a-D-Luc-ZsGreen expressing both luciferase and green fluorescent protein.
Int. J. Oncol. 48:525-532(2016)

Cross-references
Other Wikidata; Q54904594
Entry history
Entry creation23-Feb-2016
Last entry updated05-Jul-2019
Version number8