Home  |  Contact

Cellosaurus H209/VP (CVCL_9V42)

[Text version]
Cell line name H209/VP
Accession CVCL_9V42
Resource Identification Initiative To cite this cell line use: H209/VP (RRID:CVCL_9V42)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; 9884; RB1; Simple; p.Cys706Phe (c.2117G>T); ClinVar=VCV000376330; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.673-2A>T (IVS6-2A>T); ClinVar=VCV000635388; Zygosity=Homozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1525 (NCI-H209)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
Publications

PubMed=8646677; DOI=10.1002/(SICI)1097-0142(19960501)77:9<1797::AID-CNCR7>3.0.CO;2-9
Jain N., Lam Y.-M., Pym J., Campling B.G.
Mechanisms of resistance of human small cell lung cancer lines selected in VP-16 and cisplatin.
Cancer 77:1797-1808(1996)

PubMed=10699927; DOI=10.1002/(SICI)1097-0215(20000215)85:4<534::AID-IJC15>3.0.CO;2-X
Mirski S.E.L., Sparks K.E., Yu Q., Lang A.J., Jain N., Campling B.G., Cole S.P.C.
A truncated cytoplasmic topoisomerase IIalpha in a drug-resistant lung cancer cell line is encoded by a TOP2A allele with a partial deletion of exon 34.
Int. J. Cancer 85:534-539(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9V42
Encyclopedic resources Wikidata; Q54872012
Entry history
Entry creation23-Feb-2016
Last entry update05-Oct-2023
Version number10