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Cellosaurus F2.5B6 (CVCL_A041)

Cell line name F2.5B6
Synonyms F2-5B6
Accession CVCL_A041
Resource Identification Initiative To cite this cell line use: F2.5B6 (RRID:CVCL_A041)
Comments Problematic cell line: Contaminated. Shown to be a SK-HEP-1 derivative (PubMed=10508494; PubMed=20143388). Originally thought to be a thymic epithelial cell line from a 9 week old fetal thymus.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00121.
Characteristics: Has lost chromosome Y.
Sequence variations Heterozygous for BRAF p.Val600Glu (c.1799T>A) (from parent cell line).
Homozygous for CDKN2A deletion (from parent cell line).
Disease Hepatocellular carcinoma (NCIt: C3099)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0525 (SK-HEP-1)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=7514905
Fernandez E., Vicente A., Zapata A., Brera B., Lozano J.J., Martinez C., Toribio M.L.
Establishment and characterization of cloned human thymic epithelial cell lines. Analysis of adhesion molecule expression and cytokine production.
Blood 83:3245-3254(1994)

PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2
MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H., Drexler H.G.
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.
Int. J. Cancer 83:555-563(1999)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Biological sample resources BioSample; SAMN03151918
Other Wikidata; Q54833085