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Cellosaurus VCaP-CR (CVCL_A0BX)

[Text version]

Cell line name VCaP-CR
Accession CVCL_A0BX
Resource Identification Initiative To cite this cell line use: VCaP-CR (RRID:CVCL_A0BX)
Comments Population: Caucasian.
Characteristics: Derived after a passage of the parent cell line in castrated nude mice.
Doubling time: ~60 hours (DOI=10.1101/2021.07.04.450352).
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Sequence variations
  • Gene fusion; HGNC; 3446; ERG + HGNC; 11876; TMPRSS2; Name(s)=TMPRSS2-ERG (from parent cell line).
  • Mutation; HGNC; 7127; MLH1; Simple; p.Ile219Val (c.655A>G); ClinVar=VCV000036557; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Bone; vertebra.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2235 (VCaP)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Publications

DOI=10.1101/2021.07.04.450352
Haffner M.C., Bhamidipati A., Tsai H.K., Esopi D.M., Vaghasia A.M., Low J.-Y., Patel R.A., Guner G., Pham M.-T., Castagna N., Hicks J., Wyhs N., Aebersold R., De Marzo A.M., Nelson W.G., Guo T.-N., Yegnasubramanian S.
Phenotypic characterization of two novel cell line models of castration resistant prostate cancer.
bioRxiv 2021:07.04.450352-07.04.450352(2021)

Cross-references
Encyclopedic resources Wikidata; Q108821488
Gene expression databases GEO; GSM5402197
Entry history
Entry creation23-Sep-2021
Last entry update16-Dec-2021
Version number2