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Cellosaurus VCaP AR-V7/pHag (CVCL_A1BP)

[Text version]

Cell line name VCaP AR-V7/pHag
Synonyms VCaPAR-V7/pHag
Accession CVCL_A1BP
Resource Identification Initiative To cite this cell line use: VCaP AR-V7/pHag (RRID:CVCL_A1BP)
Comments Population: Caucasian.
Characteristics: Inducibly expresses AR variant 7 (ARv7).
Transfected with: HGNC; 644; AR (isoform ARv7).
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Sequence variations
  • Gene fusion; HGNC; 3446; ERG + HGNC; 11876; TMPRSS2; Name(s)=TMPRSS2-ERG (from parent cell line).
  • Mutation; HGNC; 7127; MLH1; Simple; p.Ile219Val (c.655A>G); ClinVar=VCV000036557; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Bone; vertebra.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2235 (VCaP)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=25008967; DOI=10.1016/j.biocel.2014.06.013
Krause W.C., Shafi A.A., Nakka M., Weigel N.L.
Androgen receptor and its splice variant, AR-V7, differentially regulate FOXA1 sensitive genes in LNCaP prostate cancer cells.
Int. J. Biochem. Cell Biol. 54:49-59(2014)

Cross-references
Encyclopedic resources Wikidata; Q102115093
Entry history
Entry creation29-Oct-2020
Last entry update23-Sep-2021
Version number4