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Cellosaurus TX545 (CVCL_A1SH)

[Text version]
Cell line name TX545
Accession CVCL_A1SH
Resource Identification Initiative To cite this cell line use: TX545 (RRID:CVCL_A1SH)
Comments Population: Caucasian.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Sequence variations
  • Mutation; HGNC; 11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11830; TK1; Simple; p.Ala78Argfs*27 (c.231insC); Zygosity=Heterozygous (PubMed=7859358).
  • Mutation; HGNC; 11830; TK1; Simple; p.Thr163Lys (c.488_489CC>AG); Zygosity=Heterozygous (PubMed=7859358).
Disease Hereditary spherocytosis (NCIt: C97074)
Hereditary spherocytosis (ORDO: Orphanet_822)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0561 (TK6)
Sex of cell Male
Age at sampling 5Y
Category Transformed cell line
Publications

PubMed=7859358; DOI=10.1093/carcin/16.2.267
Giver C.R., Nelson S.L. Jr., Cha M.Y., Pongsaensook P., Grosovsky A.J.
Mutational spectrum of X-ray induced TK- human cell mutants.
Carcinogenesis 16:267-275(1995)

PubMed=11404339; DOI=10.1093/genetics/158.2.757
Quintana P.J.E., Neuwirth E.A.H., Grosovsky A.J.
Interchromosomal gene conversion at an endogenous human cell locus.
Genetics 158:757-767(2001)

Cross-references
Encyclopedic resources Wikidata; Q105511281
Entry history
Entry creation12-Jan-2021
Last entry update29-Jun-2023
Version number4