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Cellosaurus UACC62-RMR (CVCL_A1VN)

[Text version]

Cell line name UACC62-RMR
Synonyms UACC62 RMR; UACC62 SKIN CJ1
Accession CVCL_A1VN
Resource Identification Initiative To cite this cell line use: UACC62-RMR (RRID:CVCL_A1VN)
Comments Selected for resistance to: ChEBI; CHEBI:75045; Dabrafenib (Tafinlar; GSK2118436).
Selected for resistance to: ChEBI; CHEBI:75998; Trametinib (Mekinist; GSK1120212).
Sequence variations Homozygous for BRAF p.Val600Glu (c.1799T>A) (ClinVar=VCV000013961) (DepMap).
Homozygous for PTEN p.Pro248Thrfs*5 (c.741dupA) (c.741_742insA) (ClinVar=VCV000142259) (DepMap).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1780 (UACC-62)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=31882401; DOI=10.1158/0008-5472.CAN-19-2330
Melms J.C., Vallabhaneni S., Mills C.E., Yapp C., Chen J.-Y., Morelli E., Waszyk P., Kumar S., Deming D., Moret N., Rodriguez S., Subramanian K., Rogava M., Cartwright A.N.R., Luoma A., Mei S., Brinker T.J., Miller D.M., Spektor A., Schadendorf D., Riggi N., Wucherpfennig K.W., Sorger P.K., Izar B.
Inhibition of haspin kinase promotes cell-intrinsic and extrinsic antitumor activity.
Cancer Res. 80:798-810(2020)

Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM01416
DepMap; ACH-002004
Entry history
Entry creation12-Jan-2021
Last entry update12-Jan-2021
Version number1