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Cellosaurus UACC62-RMR (CVCL_A1VN)

[Text version]

Cell line name UACC62-RMR
Synonyms UACC62 RMR; UACC62 SKIN CJ1
Accession CVCL_A1VN
Resource Identification Initiative To cite this cell line use: UACC62-RMR (RRID:CVCL_A1VN)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Selected for resistance to: ChEBI; CHEBI:75045; Dabrafenib (Tafinlar; GSK2118436).
Selected for resistance to: ChEBI; CHEBI:75998; Trametinib (Mekinist; GSK1120212).
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (DepMap).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Pro248Thrfs*5 (c.741dupA) (c.741_742insA); ClinVar=VCV000142259; Zygosity=Homozygous (DepMap).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1780 (UACC-62)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=31882401; DOI=10.1158/0008-5472.CAN-19-2330
Melms J.C., Vallabhaneni S., Mills C.E., Yapp C., Chen J.-Y., Morelli E., Waszyk P., Kumar S., Deming D., Moret N., Rodriguez S., Subramanian K., Rogava M., Cartwright A.N.R., Luoma A., Mei S.-L., Brinker T.J., Miller D.M., Spektor A., Schadendorf D., Riggi N., Wucherpfennig K.W., Sorger P.K., Izar B.
Inhibition of haspin kinase promotes cell-intrinsic and extrinsic antitumor activity.
Cancer Res. 80:798-810(2020)

Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM01416
DepMap; ACH-002004
Encyclopedic resources Wikidata; Q105511311
Entry history
Entry creation12-Jan-2021
Last entry update16-Dec-2021
Version number3