ID   SKBR-3-OE
AC   CVCL_A2FE
DR   cancercelllines; CVCL_A2FE
DR   Wikidata; Q105511095
RX   PubMed=33123265;
CC   Population: Caucasian.
CC   Characteristics: Using CRISPR/Cas9 a construct containing a CAG promoter-driven IGF2R gene was introduced in the AAVS1 safe harbor locus.
CC   Sequence variation: Gene deletion; HGNC; 1748; CDH1; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: HGNC; 5467; IGF2R.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0033 ! SK-BR-3
SX   Female
AG   43Y
CA   Cancer cell line
DT   Created: 12-01-21; Last updated: 05-10-23; Version: 5
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RX   PubMed=33123265; DOI=10.3892/ol.2020.12216;
RA   Ma X.-Y., Cao R., Xiao H.-Y., Cao Z.-W.;
RT   "Establishment of a type II insulin-like growth factor receptor gene
RT   site-integrated SKBR3 cell line using CRISPR/Cas9.";
RL   Oncol. Lett. 20:354.1-354.9(2020).
//