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Cellosaurus Hep G2-E43 (CVCL_A2HF)

[Text version]
Cell line name Hep G2-E43
Synonyms Hep G2-Cl2E1-43; HepG2-CYP2E1 E43; E43
Accession CVCL_A2HF
Resource Identification Initiative To cite this cell line use: Hep G2-E43 (RRID:CVCL_A2HF)
Comments Population: Caucasian.
Characteristics: Overexpresses CYP2E1.
Transfected with: HGNC; 2631; CYP2E1.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=9547353; DOI=10.1124/mol.53.4.638
Chen Q., Cederbaum A.I.
Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells.
Mol. Pharmacol. 53:638-648(1998)

PubMed=10748080; DOI=10.1074/jbc.M907022199
Mari M., Cederbaum A.I.
CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of gamma-glutamylcysteine synthetase.
J. Biol. Chem. 275:15563-15571(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2HF
Encyclopedic resources Wikidata; Q105507625
Entry history
Entry creation12-Jan-2021
Last entry update05-Oct-2023
Version number5