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Cellosaurus Hep G2-E47 (CVCL_A2HG)

[Text version]
Cell line name Hep G2-E47
Synonyms Hep G2-Cl2E1-47; HepG2-CYP2E1 E47; HepG2 E47; E47; E-47
Accession CVCL_A2HG
Resource Identification Initiative To cite this cell line use: Hep G2-E47 (RRID:CVCL_A2HG)
Comments Population: Caucasian.
Characteristics: Overexpresses CYP2E1.
Transfected with: HGNC; 2631; CYP2E1.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=9547353; DOI=10.1124/mol.53.4.638
Chen Q., Cederbaum A.I.
Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells.
Mol. Pharmacol. 53:638-648(1998)

PubMed=10748080; DOI=10.1074/jbc.M907022199
Mari M., Cederbaum A.I.
CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of gamma-glutamylcysteine synthetase.
J. Biol. Chem. 275:15563-15571(2000)

PubMed=16181800; DOI=10.1016/j.biocel.2005.07.010
Donohue T.M., Osna N.A., Clemens D.L.
Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity.
Int. J. Biochem. Cell Biol. 38:92-101(2006)

PubMed=18369917; DOI=10.1007/978-1-59745-242-7_11
Wu D.-F., Cederbaum A.I.
Development and properties of HepG2 cells that constitutively express CYP2E1.
Methods Mol. Biol. 447:137-150(2008)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2HG
Encyclopedic resources Wikidata; Q105507629
Entry history
Entry creation12-Jan-2021
Last entry update05-Oct-2023
Version number5